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COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis

Patients with chronic kidney disease on maintenance hemodialysis (HD) have a very high risk of death in the course of COVID-19. The aim of the study was to assess the effectiveness of COVID-19 vaccination to reduce the incidence of COVID-19 and the fatality rate in HD patients. A retrospective regis...

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Autores principales: Tylicki, Leszek, Biedunkiewicz, Bogdan, Puchalska-Reglińska, Ewelina, Gellert, Ryszard, Burnier, Michel, Wolf, Jacek, Dȩbska-Ślizień, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492862/
https://www.ncbi.nlm.nih.gov/pubmed/36160175
http://dx.doi.org/10.3389/fmed.2022.937167
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author Tylicki, Leszek
Biedunkiewicz, Bogdan
Puchalska-Reglińska, Ewelina
Gellert, Ryszard
Burnier, Michel
Wolf, Jacek
Dȩbska-Ślizień, Alicja
author_facet Tylicki, Leszek
Biedunkiewicz, Bogdan
Puchalska-Reglińska, Ewelina
Gellert, Ryszard
Burnier, Michel
Wolf, Jacek
Dȩbska-Ślizień, Alicja
author_sort Tylicki, Leszek
collection PubMed
description Patients with chronic kidney disease on maintenance hemodialysis (HD) have a very high risk of death in the course of COVID-19. The aim of the study was to assess the effectiveness of COVID-19 vaccination to reduce the incidence of COVID-19 and the fatality rate in HD patients. A retrospective registry-based cohort study was performed in all HD adult patients in the Pomeranian Voivodeship. Vaccinations were carried out from January to April 2021 with mRNA vaccines, either BNT162b2 or mRNA-1273 with two-dose schedule. In the first analysis (2nd pandemic wave), 1,160 unvaccinated patients were included (59.7% males, 25.7% diabetic). In the second analysis (4th pandemic wave), 1,131 (59.4% male, 30.7% diabetic) individuals were included, 1,042 (92.13%) were fully vaccinated. Three hundred and fifteen HD patients (27.2%) were COVID-19 positive during the 2nd wave, and 6.9% (78/1,131) during the 4th wave. Within the fully vaccinated patients of the 4th wave, 60 were COVID-19 positive, 5.8 vs. 20.2% of unvaccinated COVID-19 positive patients in 2nd wave, respectively. COVID-19 incidence rate ratio (IRR) was 0.21 (4th wave-vaccinated vs. 2nd wave-unvaccinated) indicating a 79% reduction. The IRR between vaccinated and unvaccinated patients of the 4th wave was 0.28 in favor of vaccinated patients with 72% reduction. In the 2nd wave, 93 patients died as a result of COVID-19 (fatality rate: 29.5%). The fatality rate of fully vaccinated patients during the 4th wave was 6.7% (p = 0.004), while the fatality rate in the 4th wave within unvaccinated patients accounted for 11.1%. Significant clinical effectiveness of COVID-19 vaccination was demonstrated in a multicenter study in HD patients.
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spelling pubmed-94928622022-09-23 COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis Tylicki, Leszek Biedunkiewicz, Bogdan Puchalska-Reglińska, Ewelina Gellert, Ryszard Burnier, Michel Wolf, Jacek Dȩbska-Ślizień, Alicja Front Med (Lausanne) Medicine Patients with chronic kidney disease on maintenance hemodialysis (HD) have a very high risk of death in the course of COVID-19. The aim of the study was to assess the effectiveness of COVID-19 vaccination to reduce the incidence of COVID-19 and the fatality rate in HD patients. A retrospective registry-based cohort study was performed in all HD adult patients in the Pomeranian Voivodeship. Vaccinations were carried out from January to April 2021 with mRNA vaccines, either BNT162b2 or mRNA-1273 with two-dose schedule. In the first analysis (2nd pandemic wave), 1,160 unvaccinated patients were included (59.7% males, 25.7% diabetic). In the second analysis (4th pandemic wave), 1,131 (59.4% male, 30.7% diabetic) individuals were included, 1,042 (92.13%) were fully vaccinated. Three hundred and fifteen HD patients (27.2%) were COVID-19 positive during the 2nd wave, and 6.9% (78/1,131) during the 4th wave. Within the fully vaccinated patients of the 4th wave, 60 were COVID-19 positive, 5.8 vs. 20.2% of unvaccinated COVID-19 positive patients in 2nd wave, respectively. COVID-19 incidence rate ratio (IRR) was 0.21 (4th wave-vaccinated vs. 2nd wave-unvaccinated) indicating a 79% reduction. The IRR between vaccinated and unvaccinated patients of the 4th wave was 0.28 in favor of vaccinated patients with 72% reduction. In the 2nd wave, 93 patients died as a result of COVID-19 (fatality rate: 29.5%). The fatality rate of fully vaccinated patients during the 4th wave was 6.7% (p = 0.004), while the fatality rate in the 4th wave within unvaccinated patients accounted for 11.1%. Significant clinical effectiveness of COVID-19 vaccination was demonstrated in a multicenter study in HD patients. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9492862/ /pubmed/36160175 http://dx.doi.org/10.3389/fmed.2022.937167 Text en Copyright © 2022 Tylicki, Biedunkiewicz, Puchalska-Reglińska, Gellert, Burnier, Wolf and Dȩbska-Ślizień. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Tylicki, Leszek
Biedunkiewicz, Bogdan
Puchalska-Reglińska, Ewelina
Gellert, Ryszard
Burnier, Michel
Wolf, Jacek
Dȩbska-Ślizień, Alicja
COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis
title COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis
title_full COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis
title_fullStr COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis
title_full_unstemmed COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis
title_short COVID-19 vaccination reduces mortality in patients on maintenance hemodialysis
title_sort covid-19 vaccination reduces mortality in patients on maintenance hemodialysis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492862/
https://www.ncbi.nlm.nih.gov/pubmed/36160175
http://dx.doi.org/10.3389/fmed.2022.937167
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