The role of RNA m6A methylation in lipid metabolism

The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metaboli...

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Autores principales: Wang, Yuting, Wang, Yujie, Gu, Jiarui, Su, Tianhong, Gu, Xiaosong, Feng, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492936/
https://www.ncbi.nlm.nih.gov/pubmed/36157445
http://dx.doi.org/10.3389/fendo.2022.866116
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author Wang, Yuting
Wang, Yujie
Gu, Jiarui
Su, Tianhong
Gu, Xiaosong
Feng, Yu
author_facet Wang, Yuting
Wang, Yujie
Gu, Jiarui
Su, Tianhong
Gu, Xiaosong
Feng, Yu
author_sort Wang, Yuting
collection PubMed
description The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metabolic regulation. The “writer” METTL3/METTL14 and the “eraser” FTO can promote the accumulation of lipids in various cells by affecting the decomposition and synthesis of lipids. The “reader” YTHDF recognizes m6A methylation sites of RNA and regulates the target genes’ translation. Due to this function that regulates lipid metabolism, RNA m6A methylation plays a pivotal role in metabolic diseases and makes it a great potential target for therapy.
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spelling pubmed-94929362022-09-23 The role of RNA m6A methylation in lipid metabolism Wang, Yuting Wang, Yujie Gu, Jiarui Su, Tianhong Gu, Xiaosong Feng, Yu Front Endocrinol (Lausanne) Endocrinology The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metabolic regulation. The “writer” METTL3/METTL14 and the “eraser” FTO can promote the accumulation of lipids in various cells by affecting the decomposition and synthesis of lipids. The “reader” YTHDF recognizes m6A methylation sites of RNA and regulates the target genes’ translation. Due to this function that regulates lipid metabolism, RNA m6A methylation plays a pivotal role in metabolic diseases and makes it a great potential target for therapy. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9492936/ /pubmed/36157445 http://dx.doi.org/10.3389/fendo.2022.866116 Text en Copyright © 2022 Wang, Wang, Gu, Su, Gu and Feng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wang, Yuting
Wang, Yujie
Gu, Jiarui
Su, Tianhong
Gu, Xiaosong
Feng, Yu
The role of RNA m6A methylation in lipid metabolism
title The role of RNA m6A methylation in lipid metabolism
title_full The role of RNA m6A methylation in lipid metabolism
title_fullStr The role of RNA m6A methylation in lipid metabolism
title_full_unstemmed The role of RNA m6A methylation in lipid metabolism
title_short The role of RNA m6A methylation in lipid metabolism
title_sort role of rna m6a methylation in lipid metabolism
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492936/
https://www.ncbi.nlm.nih.gov/pubmed/36157445
http://dx.doi.org/10.3389/fendo.2022.866116
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