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Using a competitive counterflow assay to identify novel cationic substrates of OATP1B1 and OATP1B3

OATP1B1 and OATP1B3 are two drug transporters that mediate the uptake of multiple endo- and xenobiotics, including many drugs, into human hepatocytes. Numerous inhibitors have been identified, and for some of them, it is not clear whether they are also substrates. Historically radiolabeled substrate...

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Detalles Bibliográficos
Autores principales:	Schnegelberger, Regina D., Steiert, Brianna, Sandoval, Philip J., Hagenbuch, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493024/ https://www.ncbi.nlm.nih.gov/pubmed/36160869 http://dx.doi.org/10.3389/fphys.2022.969363

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