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Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration

Disruption of blood pressure (BP) circadian rhythm, independent of hypertension, is emerging as an index for future target organ damage and is associated with a higher risk of cardiovascular events. Previous studies showed that changing food availability time alters BP rhythm in several mammalian sp...

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Autores principales: Hou, Tianfei, Chacon, Aaron N., Su, Wen, Katsumata, Yuriko, Guo, Zhenheng, Gong, Ming C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493072/
https://www.ncbi.nlm.nih.gov/pubmed/36159491
http://dx.doi.org/10.3389/fnut.2022.969345
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author Hou, Tianfei
Chacon, Aaron N.
Su, Wen
Katsumata, Yuriko
Guo, Zhenheng
Gong, Ming C.
author_facet Hou, Tianfei
Chacon, Aaron N.
Su, Wen
Katsumata, Yuriko
Guo, Zhenheng
Gong, Ming C.
author_sort Hou, Tianfei
collection PubMed
description Disruption of blood pressure (BP) circadian rhythm, independent of hypertension, is emerging as an index for future target organ damage and is associated with a higher risk of cardiovascular events. Previous studies showed that changing food availability time alters BP rhythm in several mammalian species. However, the underlying mechanisms remain largely unknown. To address this, the current study specifically investigates (1) the relationship between rhythms of food intake and BP in wild-type mice; (2) effects of light-phase time-restricted feeding (TRF, food only available during light-phase) on BP circadian rhythm in wild-type and diabetic db/db mice; (3) the roles of the autonomic system and clock gene in light-phase TRF induced changes in BP circadian rhythm. Food intake and BP of C57BL/6J and db/db mice were simultaneously and continuously recorded using BioDAQ and telemetry systems under ad libitum or light-phase TRF. Per2 protein daily oscillation was recorded in vivo by IVIS spectrum in mPer2(Luc) mice. Autonomic nerve activity was evaluated by heart rate variability, baroreflex, urinary norepinephrine (NE) and epinephrine (Epi) excretion, and mRNA expressions of catecholamines biosynthetic and catabolic enzymes, and alpha-adrenergic receptors in mesenteric resistance arteries. We found that in wild-type mice, the BP level was correlated with the food intake temporally across the 24 h. Reversing the feeding time by imposing light-phase TRF resulted in reverse or inverted BP dipping. Interestingly, the net changes in food intake were correlated with the net alteration in BP temporally under light-phase TRF. In db/db mice, light-phase TRF worsened the existing non-dipping BP. The food intake and BP circadian rhythm changes were associated with alterations in Per2 protein daily oscillation and the time-of-day variations in heart rate variability, baroreflex, and urinary excretion of NE and Epi, and increased mRNA expression of Slc6a2 (encoding NE transporter) and Adra1d (encoding alpha-adrenergic receptor 1d) in the mesenteric resistance arteries, indicating the sympathetic nervous system (SNS) was modulated after light-phase TRF. Collectively, our results demonstrated that light-phase TRF results in reverse dipping of BP in wild-type and diabetic db/db mice and revealed the potential role of the sympathetic pathway in light-phase TRF-induced BP circadian rhythm alteration.
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spelling pubmed-94930722022-09-23 Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration Hou, Tianfei Chacon, Aaron N. Su, Wen Katsumata, Yuriko Guo, Zhenheng Gong, Ming C. Front Nutr Nutrition Disruption of blood pressure (BP) circadian rhythm, independent of hypertension, is emerging as an index for future target organ damage and is associated with a higher risk of cardiovascular events. Previous studies showed that changing food availability time alters BP rhythm in several mammalian species. However, the underlying mechanisms remain largely unknown. To address this, the current study specifically investigates (1) the relationship between rhythms of food intake and BP in wild-type mice; (2) effects of light-phase time-restricted feeding (TRF, food only available during light-phase) on BP circadian rhythm in wild-type and diabetic db/db mice; (3) the roles of the autonomic system and clock gene in light-phase TRF induced changes in BP circadian rhythm. Food intake and BP of C57BL/6J and db/db mice were simultaneously and continuously recorded using BioDAQ and telemetry systems under ad libitum or light-phase TRF. Per2 protein daily oscillation was recorded in vivo by IVIS spectrum in mPer2(Luc) mice. Autonomic nerve activity was evaluated by heart rate variability, baroreflex, urinary norepinephrine (NE) and epinephrine (Epi) excretion, and mRNA expressions of catecholamines biosynthetic and catabolic enzymes, and alpha-adrenergic receptors in mesenteric resistance arteries. We found that in wild-type mice, the BP level was correlated with the food intake temporally across the 24 h. Reversing the feeding time by imposing light-phase TRF resulted in reverse or inverted BP dipping. Interestingly, the net changes in food intake were correlated with the net alteration in BP temporally under light-phase TRF. In db/db mice, light-phase TRF worsened the existing non-dipping BP. The food intake and BP circadian rhythm changes were associated with alterations in Per2 protein daily oscillation and the time-of-day variations in heart rate variability, baroreflex, and urinary excretion of NE and Epi, and increased mRNA expression of Slc6a2 (encoding NE transporter) and Adra1d (encoding alpha-adrenergic receptor 1d) in the mesenteric resistance arteries, indicating the sympathetic nervous system (SNS) was modulated after light-phase TRF. Collectively, our results demonstrated that light-phase TRF results in reverse dipping of BP in wild-type and diabetic db/db mice and revealed the potential role of the sympathetic pathway in light-phase TRF-induced BP circadian rhythm alteration. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493072/ /pubmed/36159491 http://dx.doi.org/10.3389/fnut.2022.969345 Text en Copyright © 2022 Hou, Chacon, Su, Katsumata, Guo and Gong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Hou, Tianfei
Chacon, Aaron N.
Su, Wen
Katsumata, Yuriko
Guo, Zhenheng
Gong, Ming C.
Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
title Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
title_full Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
title_fullStr Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
title_full_unstemmed Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
title_short Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
title_sort role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493072/
https://www.ncbi.nlm.nih.gov/pubmed/36159491
http://dx.doi.org/10.3389/fnut.2022.969345
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