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Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain accompanied by synaptic dysfunction and neurodegeneration. No effective treatment has been found to slow the progression of the disease. Therap...

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Autores principales: Tozlu, Özlem Özdemir, Türkez, Hasan, Okkay, Ufuk, Ceylan, Onur, Bayram, Cemil, Hacımüftüoğlu, Ahmet, Mardinoğlu, Adil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493202/
https://www.ncbi.nlm.nih.gov/pubmed/36159454
http://dx.doi.org/10.3389/fnut.2022.981889
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author Tozlu, Özlem Özdemir
Türkez, Hasan
Okkay, Ufuk
Ceylan, Onur
Bayram, Cemil
Hacımüftüoğlu, Ahmet
Mardinoğlu, Adil
author_facet Tozlu, Özlem Özdemir
Türkez, Hasan
Okkay, Ufuk
Ceylan, Onur
Bayram, Cemil
Hacımüftüoğlu, Ahmet
Mardinoğlu, Adil
author_sort Tozlu, Özlem Özdemir
collection PubMed
description Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain accompanied by synaptic dysfunction and neurodegeneration. No effective treatment has been found to slow the progression of the disease. Therapeutic studies using experimental animal models have therefore become very important. Therefore, this study aimed to investigate the possible neuroprotective effect of D-cycloserine and L-serine against aluminum chloride (AlCl(3))-induced AD in rats. Administration of AlCl(3) for 28 days caused oxidative stress and neurodegeneration compared to the control group. In addition, we found that aluminum decreases α-secretase activity while increasing β-secretase and γ-secretase activities by molecular genetic analysis. D-cycloserine and L-serine application resulted in an improvement in neurodegeneration and oxidative damage caused by aluminum toxicity. It is believed that the results of this study will contribute to the synthesis of new compounds with improved potential against AlCl(3)-induced neurodegeneration, cognitive impairment, and drug development research.
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spelling pubmed-94932022022-09-23 Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies Tozlu, Özlem Özdemir Türkez, Hasan Okkay, Ufuk Ceylan, Onur Bayram, Cemil Hacımüftüoğlu, Ahmet Mardinoğlu, Adil Front Nutr Nutrition Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain accompanied by synaptic dysfunction and neurodegeneration. No effective treatment has been found to slow the progression of the disease. Therapeutic studies using experimental animal models have therefore become very important. Therefore, this study aimed to investigate the possible neuroprotective effect of D-cycloserine and L-serine against aluminum chloride (AlCl(3))-induced AD in rats. Administration of AlCl(3) for 28 days caused oxidative stress and neurodegeneration compared to the control group. In addition, we found that aluminum decreases α-secretase activity while increasing β-secretase and γ-secretase activities by molecular genetic analysis. D-cycloserine and L-serine application resulted in an improvement in neurodegeneration and oxidative damage caused by aluminum toxicity. It is believed that the results of this study will contribute to the synthesis of new compounds with improved potential against AlCl(3)-induced neurodegeneration, cognitive impairment, and drug development research. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493202/ /pubmed/36159454 http://dx.doi.org/10.3389/fnut.2022.981889 Text en Copyright © 2022 Tozlu, Türkez, Okkay, Ceylan, Bayram, Hacımüftüoğlu and Mardinoğlu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Tozlu, Özlem Özdemir
Türkez, Hasan
Okkay, Ufuk
Ceylan, Onur
Bayram, Cemil
Hacımüftüoğlu, Ahmet
Mardinoğlu, Adil
Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies
title Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies
title_full Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies
title_fullStr Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies
title_full_unstemmed Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies
title_short Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer’s disease: In vivo and in vitro studies
title_sort assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of alzheimer’s disease: in vivo and in vitro studies
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493202/
https://www.ncbi.nlm.nih.gov/pubmed/36159454
http://dx.doi.org/10.3389/fnut.2022.981889
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