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Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications
Diabetes‐related lower extremity amputations are an enormous burden on global health care and social resources because of the rapid worldwide growth of the diabetic population. This research aimed to determine risk factors that predict major amputation and analyse the time interval from first hospit...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493235/ https://www.ncbi.nlm.nih.gov/pubmed/34879446 http://dx.doi.org/10.1111/iwj.13727 |
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author | Chou, Yu‐Yu Hou, Chin‐Chun Wu, Chien‐Wei Huang, Dun‐Wei Tsai, Sheng‐Lin Liu, Ting‐Hsuan Ding, Lu‐Ming Chang, Chun‐Kai Ou, Kuang‐Ling Chiu, Yu‐Lung Tzeng, Yuan‐Sheng |
author_facet | Chou, Yu‐Yu Hou, Chin‐Chun Wu, Chien‐Wei Huang, Dun‐Wei Tsai, Sheng‐Lin Liu, Ting‐Hsuan Ding, Lu‐Ming Chang, Chun‐Kai Ou, Kuang‐Ling Chiu, Yu‐Lung Tzeng, Yuan‐Sheng |
author_sort | Chou, Yu‐Yu |
collection | PubMed |
description | Diabetes‐related lower extremity amputations are an enormous burden on global health care and social resources because of the rapid worldwide growth of the diabetic population. This research aimed to determine risk factors that predict major amputation and analyse the time interval from first hospitalisation to amputation by using standard management protocols and Kaplan–Meier survival curves. Data from 246 patients with diabetes mellitus and diabetic foot ulcers from the Division of Plastic and Reconstructive Surgery of the Department of Surgery at XXX Hospital between January 2016 and May 2020 were analysed. Univariate and multivariate analyses of 44 potential risk factors, including invasive ulcer depth and C‐reactive protein levels, showed statistically significant differences for those at increased risk for major amputation. The median time from hospitalisation to lower extremity amputation was approximately 35 days. Most patients with abnormal C‐reactive protein levels and approximately 70% of patients with ulcers invading the bone were at risk for lower extremity amputations within 35 days. Therefore, invasive ulcer depth and C‐reactive protein levels are significant risk factors. Other potential risk factors for major amputation and the time intervals from first hospitalisation to amputation should be analysed to establish further prediction strategies. |
format | Online Article Text |
id | pubmed-9493235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-94932352022-09-30 Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications Chou, Yu‐Yu Hou, Chin‐Chun Wu, Chien‐Wei Huang, Dun‐Wei Tsai, Sheng‐Lin Liu, Ting‐Hsuan Ding, Lu‐Ming Chang, Chun‐Kai Ou, Kuang‐Ling Chiu, Yu‐Lung Tzeng, Yuan‐Sheng Int Wound J Original Articles Diabetes‐related lower extremity amputations are an enormous burden on global health care and social resources because of the rapid worldwide growth of the diabetic population. This research aimed to determine risk factors that predict major amputation and analyse the time interval from first hospitalisation to amputation by using standard management protocols and Kaplan–Meier survival curves. Data from 246 patients with diabetes mellitus and diabetic foot ulcers from the Division of Plastic and Reconstructive Surgery of the Department of Surgery at XXX Hospital between January 2016 and May 2020 were analysed. Univariate and multivariate analyses of 44 potential risk factors, including invasive ulcer depth and C‐reactive protein levels, showed statistically significant differences for those at increased risk for major amputation. The median time from hospitalisation to lower extremity amputation was approximately 35 days. Most patients with abnormal C‐reactive protein levels and approximately 70% of patients with ulcers invading the bone were at risk for lower extremity amputations within 35 days. Therefore, invasive ulcer depth and C‐reactive protein levels are significant risk factors. Other potential risk factors for major amputation and the time intervals from first hospitalisation to amputation should be analysed to establish further prediction strategies. Blackwell Publishing Ltd 2021-12-08 /pmc/articles/PMC9493235/ /pubmed/34879446 http://dx.doi.org/10.1111/iwj.13727 Text en © 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Chou, Yu‐Yu Hou, Chin‐Chun Wu, Chien‐Wei Huang, Dun‐Wei Tsai, Sheng‐Lin Liu, Ting‐Hsuan Ding, Lu‐Ming Chang, Chun‐Kai Ou, Kuang‐Ling Chiu, Yu‐Lung Tzeng, Yuan‐Sheng Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
title | Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
title_full | Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
title_fullStr | Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
title_full_unstemmed | Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
title_short | Risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
title_sort | risk factors that predict major amputations and amputation time intervals for hospitalised diabetic patients with foot complications |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493235/ https://www.ncbi.nlm.nih.gov/pubmed/34879446 http://dx.doi.org/10.1111/iwj.13727 |
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