Cargando…

A high throughput method for Monitoring of Sorafenib, regorafenib, cabozantinib and their metabolites with UPLC-MS/MS in rat plasma

As multi-targeted tyrosine kinase inhibitors, sorafenib, regorafenib and cabozantinib are widely used in hepatocellular carcinoma (HCC) for systemic therapies with anti-proliferative and anti-angiogenic effects. Nevertheless, adverse effects or insufficient efficacy appear frequently due to the plas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Er-Min, Liu, Ya-Nan, Pan, Lvjun, Hu, Yingying, Ye, Xuemei, Luo, Pingping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493307/ https://www.ncbi.nlm.nih.gov/pubmed/36160432 http://dx.doi.org/10.3389/fphar.2022.955263

Ejemplares similares

Quantification of cobimetinib, cabozantinib, dabrafenib, niraparib, olaparib, vemurafenib, regorafenib and its metabolite regorafenib M2 in human plasma by UPLC–MS/MS
por: Krens, Stefanie D., et al.
Publicado: (2020)

An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma
por: Xing, Liying, et al.
Publicado: (2022)

UPLC-MS/MS Technology for the Quantitative Methodology and Pharmacokinetic Analysis of Voxtalisib in Rat Plasma
por: Li, Qingqing, et al.
Publicado: (2022)

Effect of Baicalein on the Pharmacokinetics of Cilostazol and Its Two Metabolites in Rat Plasma Using UPLC-MS/MS Method
por: Weng, Qinghua, et al.
Publicado: (2022)

Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics
por: Liu, Ya-nan, et al.
Publicado: (2022)

A Novel UPLC-MS/MS Assay for the Measurement of Linezolid and its Metabolite PNU-142300 in Human Serum and its Application to Patients With Renal Insufficiency
por: Wang, Yingying, et al.
Publicado: (2021)

Establishment of a sensitive UPLC-MS/MS method to quantify safinamide in rat plasma
por: Wang, Ying, et al.
Publicado: (2023)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
por: Li, Ming, et al.
Publicado: (2022)

Effect of Sophocarpine on the Pharmacokinetics of Umbralisib in Rat Plasma Using a Novel UPLC-MS/MS Method
por: Weng, Qinghua, et al.
Publicado: (2022)

UPLC-MS/MS method for Icariin and metabolites in whole blood of C57 mice: development, validation, and pharmacokinetics study
por: Liu, Wei, et al.
Publicado: (2023)

Development of a UPLC-MS/MS method for the determination of lacosamide and its metabolite and its application to drug-drug interaction
por: Chen, Jie, et al.
Publicado: (2023)

Development of a robust UPLC-MS/MS method for the quantification of riluzole in human plasma and its application in pharmacokinetics
por: Sun, Zhuo, et al.
Publicado: (2023)

UPLC-MS/MS Determination of Linezolid and Heme in Plasma of Infected Patients and Correlation Analysis
por: Wang, Yingying, et al.
Publicado: (2021)

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS
por: Zhang, Chenning, et al.
Publicado: (2018)

The Effect of Posaconazole and Isavuconazole on the Pharmacokinetics of Erdafitinib in Beagle Dogs by UPLC-MS/MS
por: Ruan, Lan-hong, et al.
Publicado: (2021)

Characterization of Alpelisib in Rat Plasma by a Newly Developed UPLC-MS/MS Method: Application to a Drug-Drug Interaction Study
por: Wang, Qiong, et al.
Publicado: (2021)

Rapid Determination of 9 Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma in Human Plasma by QuEChERS-UPLC-MS/MS
por: Jiang, Wen, et al.
Publicado: (2022)

Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma
por: Lu, Shijia, et al.
Publicado: (2023)

Quantitation of mycophenolic acid and metabolites by UPLC-MS/MS in renal transplant patients
por: Huang, Yun-Fen, et al.
Publicado: (2022)

A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma
por: Li, Xia, et al.
Publicado: (2023)

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
por: Saad, Moayad, et al.
Publicado: (2017)

Development of UPLC-MS/MS Method to Study the Pharmacokinetic Interaction between Sorafenib and Dapagliflozin in Rats
por: He, Xueru, et al.
Publicado: (2022)

Profiling and Distribution of Metabolites of Procyanidin B2 in Mice by UPLC-DAD-ESI-IT-TOF-MS(n) Technique
por: Xiao, Ying, et al.
Publicado: (2017)

Metabolite Profiling of Dihydroartemisinin in Blood of Plasmodium-Infected and Healthy Mice Using UPLC-Q-TOF-MS(E)
por: Zhao, Yifan, et al.
Publicado: (2021)

Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats
por: Altalal, Alanoud, et al.
Publicado: (2023)

Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide
por: Harahap, Yahdiana, et al.
Publicado: (2022)

New UPLC–MS/MS assay for the determination of tamoxifen and its metabolites in human plasma, application to patients
por: Bobin-Dubigeon, Christine, et al.
Publicado: (2019)

Plasma Pharmacokinetic Determination of Canagliflozin and Its Metabolites in a Type 2 Diabetic Rat Model by UPLC-MS/MS
por: Dong, Song-tao, et al.
Publicado: (2018)

Determination of candesartan or olmesartan in hypertensive patient plasma using UPLC-MS/MS
por: Jeong, Hyeon-Cheol, et al.
Publicado: (2021)

Simultaneous determination of five essential amino acids in plasma of Hyperlipidemic subjects by UPLC-MS/MS
por: Chen, Zhibin, et al.
Publicado: (2020)

How Aconiti Radix Cocta can Treat Gouty Arthritis Based on Systematic Pharmacology and UPLC-QTOF-MS/MS
por: Ye, Xietao, et al.
Publicado: (2021)

Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation
por: Liu, Hongda, et al.
Publicado: (2022)

Analysis of Flavonoid Metabolites in Buckwheat Leaves Using UPLC-ESI-MS/MS
por: Li, Jing, et al.
Publicado: (2019)

Analysis of Flavonoid Metabolites in Chaenomeles Petals Using UPLC-ESI-MS/MS
por: Shen, Ting, et al.
Publicado: (2020)

Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS
por: Liu, Mengting, et al.
Publicado: (2023)

High-Throughput Analysis of Water-Soluble Forms of Choline and Related Metabolites in Human Milk by UPLC-MS/MS and Its Application
por: Hampel, Daniela, et al.
Publicado: (2021)

Quick and Sensitive UPLC-ESI-MS/MS Method for Simultaneous Estimation of Sofosbuvir and Its Metabolite in Human Plasma
por: Semreen, Mohammad H., et al.
Publicado: (2019)

Multi-component pharmacokinetic study of prunus mume fructus extract after oral administration in rats using UPLC-MS/MS
por: Zhu, Yameng, et al.
Publicado: (2022)

Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS
por: Wu, Di, et al.
Publicado: (2018)

Development of a UPLC-ESI-MS/MS method for the determination of triamcinolone acetonide in human plasma and evaluation of its bioequivalence after a single intramuscular injection in healthy volunteers
por: Zhao, Pengfei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_47msun9ecm9o2eeuorm79csv5u