Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance

Phenylacetic acid (PAA) is a central intermediate metabolite involved in bacterial degradation of aromatic components. The bacterial PAA pathway mainly contains 12 enzymes and a transcriptional regulator, which are involved in biofilm formation and antimicrobial activity. They are present in approxi...

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Autores principales: Jiao, Min, He, Wenbo, Ouyang, Zhenlin, Shi, Qindong, Wen, Yurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493321/
https://www.ncbi.nlm.nih.gov/pubmed/36160191
http://dx.doi.org/10.3389/fmicb.2022.964019
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author Jiao, Min
He, Wenbo
Ouyang, Zhenlin
Shi, Qindong
Wen, Yurong
author_facet Jiao, Min
He, Wenbo
Ouyang, Zhenlin
Shi, Qindong
Wen, Yurong
author_sort Jiao, Min
collection PubMed
description Phenylacetic acid (PAA) is a central intermediate metabolite involved in bacterial degradation of aromatic components. The bacterial PAA pathway mainly contains 12 enzymes and a transcriptional regulator, which are involved in biofilm formation and antimicrobial activity. They are present in approximately 16% of the sequenced bacterial genome. In this review, we have summarized the PAA distribution in microbes, recent structural and functional study progress of the enzyme families of the bacterial PAA pathway, and their role in bacterial pathogenicity and antibiotic resistance. The enzymes of the bacterial PAA pathway have shown potential as an antimicrobial drug target for biotechnological applications in metabolic engineering.
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spelling pubmed-94933212022-09-23 Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance Jiao, Min He, Wenbo Ouyang, Zhenlin Shi, Qindong Wen, Yurong Front Microbiol Microbiology Phenylacetic acid (PAA) is a central intermediate metabolite involved in bacterial degradation of aromatic components. The bacterial PAA pathway mainly contains 12 enzymes and a transcriptional regulator, which are involved in biofilm formation and antimicrobial activity. They are present in approximately 16% of the sequenced bacterial genome. In this review, we have summarized the PAA distribution in microbes, recent structural and functional study progress of the enzyme families of the bacterial PAA pathway, and their role in bacterial pathogenicity and antibiotic resistance. The enzymes of the bacterial PAA pathway have shown potential as an antimicrobial drug target for biotechnological applications in metabolic engineering. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493321/ /pubmed/36160191 http://dx.doi.org/10.3389/fmicb.2022.964019 Text en Copyright © 2022 Jiao, He, Ouyang, Shi and Wen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Jiao, Min
He, Wenbo
Ouyang, Zhenlin
Shi, Qindong
Wen, Yurong
Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
title Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
title_full Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
title_fullStr Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
title_full_unstemmed Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
title_short Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
title_sort progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493321/
https://www.ncbi.nlm.nih.gov/pubmed/36160191
http://dx.doi.org/10.3389/fmicb.2022.964019
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