Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice

Metformin is widely used to surmount insulin resistance (IR) and type 2 diabetes. Accumulating evidence suggests that metformin may improve IR through regulating gut microbiota and bile acids. However, the underlying mechanisms remain unclear. Our metabolomic analysis showed that metformin significa...

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Detalles Bibliográficos
Autores principales: Zhang, Ya, Cheng, Yang, Liu, Jian, Zuo, Jihui, Yan, Liping, Thring, Ronald W., Ba, Xueqing, Qi, Dake, Wu, Mingjiang, Gao, Yitian, Tong, Haibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493383/
https://www.ncbi.nlm.nih.gov/pubmed/36148770
http://dx.doi.org/10.1016/j.redox.2022.102481

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