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Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial
BACKGROUND: Cognitive impairment affects 50%–75% of people with secondary progressive multiple sclerosis (PwSPMS). Improving our ability to predict cognitive decline may facilitate earlier intervention. OBJECTIVE: The main aim of this study was to assess the relationship between longitudinal changes...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493411/ https://www.ncbi.nlm.nih.gov/pubmed/35946107 http://dx.doi.org/10.1177/13524585221114441 |
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author | Williams, Thomas Tur, Carmen Eshaghi, Arman Doshi, Anisha Chan, Dennis Binks, Sophie Wellington, Henny Heslegrave, Amanda Zetterberg, Henrik Chataway, Jeremy |
author_facet | Williams, Thomas Tur, Carmen Eshaghi, Arman Doshi, Anisha Chan, Dennis Binks, Sophie Wellington, Henny Heslegrave, Amanda Zetterberg, Henrik Chataway, Jeremy |
author_sort | Williams, Thomas |
collection | PubMed |
description | BACKGROUND: Cognitive impairment affects 50%–75% of people with secondary progressive multiple sclerosis (PwSPMS). Improving our ability to predict cognitive decline may facilitate earlier intervention. OBJECTIVE: The main aim of this study was to assess the relationship between longitudinal changes in cognition and baseline serum neurofilament light chain (sNfL) in PwSPMS. In a multi-modal analysis, MRI variables were additionally included to determine if sNfL has predictive utility beyond that already established through MRI. METHODS: Participants from the MS-STAT trial underwent a detailed neuropsychological test battery at baseline, 12 and 24 months. Linear mixed models were used to assess the relationships between cognition, sNfL, T2 lesion volume (T2LV) and normalised regional brain volumes. RESULTS: Median age and Expanded Disability Status Score (EDSS) were 51 and 6.0. Each doubling of baseline sNfL was associated with a 0.010 [0.003–0.017] point per month faster decline in WASI Full Scale IQ Z-score (p = 0.008), independent of T2LV and normalised regional volumes. In contrast, lower baseline volume of the transverse temporal gyrus was associated with poorer current cognitive performance (0.362 [0.026–0.698] point reduction per mL, p = 0.035), but not change in cognition. The results were supported by secondary analyses on individual cognitive components. CONCLUSION: Elevated sNfL is associated with faster cognitive decline, independent of T2LV and regional normalised volumes. |
format | Online Article Text |
id | pubmed-9493411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-94934112022-09-23 Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial Williams, Thomas Tur, Carmen Eshaghi, Arman Doshi, Anisha Chan, Dennis Binks, Sophie Wellington, Henny Heslegrave, Amanda Zetterberg, Henrik Chataway, Jeremy Mult Scler Original Research Papers BACKGROUND: Cognitive impairment affects 50%–75% of people with secondary progressive multiple sclerosis (PwSPMS). Improving our ability to predict cognitive decline may facilitate earlier intervention. OBJECTIVE: The main aim of this study was to assess the relationship between longitudinal changes in cognition and baseline serum neurofilament light chain (sNfL) in PwSPMS. In a multi-modal analysis, MRI variables were additionally included to determine if sNfL has predictive utility beyond that already established through MRI. METHODS: Participants from the MS-STAT trial underwent a detailed neuropsychological test battery at baseline, 12 and 24 months. Linear mixed models were used to assess the relationships between cognition, sNfL, T2 lesion volume (T2LV) and normalised regional brain volumes. RESULTS: Median age and Expanded Disability Status Score (EDSS) were 51 and 6.0. Each doubling of baseline sNfL was associated with a 0.010 [0.003–0.017] point per month faster decline in WASI Full Scale IQ Z-score (p = 0.008), independent of T2LV and normalised regional volumes. In contrast, lower baseline volume of the transverse temporal gyrus was associated with poorer current cognitive performance (0.362 [0.026–0.698] point reduction per mL, p = 0.035), but not change in cognition. The results were supported by secondary analyses on individual cognitive components. CONCLUSION: Elevated sNfL is associated with faster cognitive decline, independent of T2LV and regional normalised volumes. SAGE Publications 2022-08-09 2022-10 /pmc/articles/PMC9493411/ /pubmed/35946107 http://dx.doi.org/10.1177/13524585221114441 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Papers Williams, Thomas Tur, Carmen Eshaghi, Arman Doshi, Anisha Chan, Dennis Binks, Sophie Wellington, Henny Heslegrave, Amanda Zetterberg, Henrik Chataway, Jeremy Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial |
title | Serum neurofilament light and MRI predictors of cognitive decline in
patients with secondary progressive multiple sclerosis: Analysis from the
MS-STAT randomised controlled trial |
title_full | Serum neurofilament light and MRI predictors of cognitive decline in
patients with secondary progressive multiple sclerosis: Analysis from the
MS-STAT randomised controlled trial |
title_fullStr | Serum neurofilament light and MRI predictors of cognitive decline in
patients with secondary progressive multiple sclerosis: Analysis from the
MS-STAT randomised controlled trial |
title_full_unstemmed | Serum neurofilament light and MRI predictors of cognitive decline in
patients with secondary progressive multiple sclerosis: Analysis from the
MS-STAT randomised controlled trial |
title_short | Serum neurofilament light and MRI predictors of cognitive decline in
patients with secondary progressive multiple sclerosis: Analysis from the
MS-STAT randomised controlled trial |
title_sort | serum neurofilament light and mri predictors of cognitive decline in
patients with secondary progressive multiple sclerosis: analysis from the
ms-stat randomised controlled trial |
topic | Original Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493411/ https://www.ncbi.nlm.nih.gov/pubmed/35946107 http://dx.doi.org/10.1177/13524585221114441 |
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