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Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis

BACKGROUND: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. OBJECTIVE: The aim of the study is to investigate the associat...

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Autores principales: Brune, Synne, Høgestøl, Einar A, de Rodez Benavent, Sigrid A, Berg-Hansen, Pål, Beyer, Mona K, Leikfoss, Ingvild Sørum, Bos, Steffan D, Sowa, Piotr, Brunborg, Cathrine, Andorra, Magi, Pulido Valdeolivas, Irene, Asseyer, Susanna, Brandt, Alexander, Chien, Claudia, Scheel, Michael, Blennow, Kaj, Zetterberg, Henrik, Kerlero de Rosbo, Nicole, Paul, Friedemann, Uccelli, Antonio, Villoslada, Pablo, Berge, Tone, Harbo, Hanne F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493412/
https://www.ncbi.nlm.nih.gov/pubmed/35658739
http://dx.doi.org/10.1177/13524585221097296
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author Brune, Synne
Høgestøl, Einar A
de Rodez Benavent, Sigrid A
Berg-Hansen, Pål
Beyer, Mona K
Leikfoss, Ingvild Sørum
Bos, Steffan D
Sowa, Piotr
Brunborg, Cathrine
Andorra, Magi
Pulido Valdeolivas, Irene
Asseyer, Susanna
Brandt, Alexander
Chien, Claudia
Scheel, Michael
Blennow, Kaj
Zetterberg, Henrik
Kerlero de Rosbo, Nicole
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Berge, Tone
Harbo, Hanne F
author_facet Brune, Synne
Høgestøl, Einar A
de Rodez Benavent, Sigrid A
Berg-Hansen, Pål
Beyer, Mona K
Leikfoss, Ingvild Sørum
Bos, Steffan D
Sowa, Piotr
Brunborg, Cathrine
Andorra, Magi
Pulido Valdeolivas, Irene
Asseyer, Susanna
Brandt, Alexander
Chien, Claudia
Scheel, Michael
Blennow, Kaj
Zetterberg, Henrik
Kerlero de Rosbo, Nicole
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Berge, Tone
Harbo, Hanne F
author_sort Brune, Synne
collection PubMed
description BACKGROUND: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. OBJECTIVE: The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort. METHODS: MS patients (n = 309) were prospectively enrolled at four centres and re-examined after 2 years (n = 226). NfL concentration was measured by single molecule array assay in serum. The patients’ phenotypes were thoroughly characterized with clinical examination, retinal OCT and MRI brain scans. The primary outcome was disease worsening at median 2-year follow-up. RESULTS: Patients with high sNfL concentrations (⩾8 pg/mL) at baseline had increased risk of disease worsening at median 2-year follow-up (odds ratio (95% confidence interval) = 2.8 (1.5–5.3), p = 0.001). We found no significant associations of MRI or OCT measures at baseline with risk of disease worsening. CONCLUSION: Serum NfL concentration was the only factor associated with disease worsening, indicating that sNfL is a useful biomarker in MS that might be relevant in a clinical setting.
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spelling pubmed-94934122022-09-23 Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis Brune, Synne Høgestøl, Einar A de Rodez Benavent, Sigrid A Berg-Hansen, Pål Beyer, Mona K Leikfoss, Ingvild Sørum Bos, Steffan D Sowa, Piotr Brunborg, Cathrine Andorra, Magi Pulido Valdeolivas, Irene Asseyer, Susanna Brandt, Alexander Chien, Claudia Scheel, Michael Blennow, Kaj Zetterberg, Henrik Kerlero de Rosbo, Nicole Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Berge, Tone Harbo, Hanne F Mult Scler Original Research Papers BACKGROUND: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. OBJECTIVE: The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort. METHODS: MS patients (n = 309) were prospectively enrolled at four centres and re-examined after 2 years (n = 226). NfL concentration was measured by single molecule array assay in serum. The patients’ phenotypes were thoroughly characterized with clinical examination, retinal OCT and MRI brain scans. The primary outcome was disease worsening at median 2-year follow-up. RESULTS: Patients with high sNfL concentrations (⩾8 pg/mL) at baseline had increased risk of disease worsening at median 2-year follow-up (odds ratio (95% confidence interval) = 2.8 (1.5–5.3), p = 0.001). We found no significant associations of MRI or OCT measures at baseline with risk of disease worsening. CONCLUSION: Serum NfL concentration was the only factor associated with disease worsening, indicating that sNfL is a useful biomarker in MS that might be relevant in a clinical setting. SAGE Publications 2022-06-04 2022-10 /pmc/articles/PMC9493412/ /pubmed/35658739 http://dx.doi.org/10.1177/13524585221097296 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Papers
Brune, Synne
Høgestøl, Einar A
de Rodez Benavent, Sigrid A
Berg-Hansen, Pål
Beyer, Mona K
Leikfoss, Ingvild Sørum
Bos, Steffan D
Sowa, Piotr
Brunborg, Cathrine
Andorra, Magi
Pulido Valdeolivas, Irene
Asseyer, Susanna
Brandt, Alexander
Chien, Claudia
Scheel, Michael
Blennow, Kaj
Zetterberg, Henrik
Kerlero de Rosbo, Nicole
Paul, Friedemann
Uccelli, Antonio
Villoslada, Pablo
Berge, Tone
Harbo, Hanne F
Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
title Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
title_full Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
title_fullStr Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
title_full_unstemmed Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
title_short Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
title_sort serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
topic Original Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493412/
https://www.ncbi.nlm.nih.gov/pubmed/35658739
http://dx.doi.org/10.1177/13524585221097296
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