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Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis
BACKGROUND: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. OBJECTIVE: The aim of the study is to investigate the associat...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493412/ https://www.ncbi.nlm.nih.gov/pubmed/35658739 http://dx.doi.org/10.1177/13524585221097296 |
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author | Brune, Synne Høgestøl, Einar A de Rodez Benavent, Sigrid A Berg-Hansen, Pål Beyer, Mona K Leikfoss, Ingvild Sørum Bos, Steffan D Sowa, Piotr Brunborg, Cathrine Andorra, Magi Pulido Valdeolivas, Irene Asseyer, Susanna Brandt, Alexander Chien, Claudia Scheel, Michael Blennow, Kaj Zetterberg, Henrik Kerlero de Rosbo, Nicole Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Berge, Tone Harbo, Hanne F |
author_facet | Brune, Synne Høgestøl, Einar A de Rodez Benavent, Sigrid A Berg-Hansen, Pål Beyer, Mona K Leikfoss, Ingvild Sørum Bos, Steffan D Sowa, Piotr Brunborg, Cathrine Andorra, Magi Pulido Valdeolivas, Irene Asseyer, Susanna Brandt, Alexander Chien, Claudia Scheel, Michael Blennow, Kaj Zetterberg, Henrik Kerlero de Rosbo, Nicole Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Berge, Tone Harbo, Hanne F |
author_sort | Brune, Synne |
collection | PubMed |
description | BACKGROUND: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. OBJECTIVE: The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort. METHODS: MS patients (n = 309) were prospectively enrolled at four centres and re-examined after 2 years (n = 226). NfL concentration was measured by single molecule array assay in serum. The patients’ phenotypes were thoroughly characterized with clinical examination, retinal OCT and MRI brain scans. The primary outcome was disease worsening at median 2-year follow-up. RESULTS: Patients with high sNfL concentrations (⩾8 pg/mL) at baseline had increased risk of disease worsening at median 2-year follow-up (odds ratio (95% confidence interval) = 2.8 (1.5–5.3), p = 0.001). We found no significant associations of MRI or OCT measures at baseline with risk of disease worsening. CONCLUSION: Serum NfL concentration was the only factor associated with disease worsening, indicating that sNfL is a useful biomarker in MS that might be relevant in a clinical setting. |
format | Online Article Text |
id | pubmed-9493412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-94934122022-09-23 Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis Brune, Synne Høgestøl, Einar A de Rodez Benavent, Sigrid A Berg-Hansen, Pål Beyer, Mona K Leikfoss, Ingvild Sørum Bos, Steffan D Sowa, Piotr Brunborg, Cathrine Andorra, Magi Pulido Valdeolivas, Irene Asseyer, Susanna Brandt, Alexander Chien, Claudia Scheel, Michael Blennow, Kaj Zetterberg, Henrik Kerlero de Rosbo, Nicole Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Berge, Tone Harbo, Hanne F Mult Scler Original Research Papers BACKGROUND: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. OBJECTIVE: The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort. METHODS: MS patients (n = 309) were prospectively enrolled at four centres and re-examined after 2 years (n = 226). NfL concentration was measured by single molecule array assay in serum. The patients’ phenotypes were thoroughly characterized with clinical examination, retinal OCT and MRI brain scans. The primary outcome was disease worsening at median 2-year follow-up. RESULTS: Patients with high sNfL concentrations (⩾8 pg/mL) at baseline had increased risk of disease worsening at median 2-year follow-up (odds ratio (95% confidence interval) = 2.8 (1.5–5.3), p = 0.001). We found no significant associations of MRI or OCT measures at baseline with risk of disease worsening. CONCLUSION: Serum NfL concentration was the only factor associated with disease worsening, indicating that sNfL is a useful biomarker in MS that might be relevant in a clinical setting. SAGE Publications 2022-06-04 2022-10 /pmc/articles/PMC9493412/ /pubmed/35658739 http://dx.doi.org/10.1177/13524585221097296 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Papers Brune, Synne Høgestøl, Einar A de Rodez Benavent, Sigrid A Berg-Hansen, Pål Beyer, Mona K Leikfoss, Ingvild Sørum Bos, Steffan D Sowa, Piotr Brunborg, Cathrine Andorra, Magi Pulido Valdeolivas, Irene Asseyer, Susanna Brandt, Alexander Chien, Claudia Scheel, Michael Blennow, Kaj Zetterberg, Henrik Kerlero de Rosbo, Nicole Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Berge, Tone Harbo, Hanne F Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis |
title | Serum neurofilament light chain concentration predicts disease
worsening in multiple sclerosis |
title_full | Serum neurofilament light chain concentration predicts disease
worsening in multiple sclerosis |
title_fullStr | Serum neurofilament light chain concentration predicts disease
worsening in multiple sclerosis |
title_full_unstemmed | Serum neurofilament light chain concentration predicts disease
worsening in multiple sclerosis |
title_short | Serum neurofilament light chain concentration predicts disease
worsening in multiple sclerosis |
title_sort | serum neurofilament light chain concentration predicts disease
worsening in multiple sclerosis |
topic | Original Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493412/ https://www.ncbi.nlm.nih.gov/pubmed/35658739 http://dx.doi.org/10.1177/13524585221097296 |
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