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The role of brain derived neurotrophic factor in central nervous system
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presen...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493475/ https://www.ncbi.nlm.nih.gov/pubmed/36158555 http://dx.doi.org/10.3389/fnagi.2022.986443 |
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author | Li, Yiyi Li, Fang Qin, Dongdong Chen, Hongyu Wang, Jianhao Wang, Jiabei Song, Shafei Wang, Chao Wang, Yamei Liu, Songyan Gao, Dandan Wang, Zhi-Hao |
author_facet | Li, Yiyi Li, Fang Qin, Dongdong Chen, Hongyu Wang, Jianhao Wang, Jiabei Song, Shafei Wang, Chao Wang, Yamei Liu, Songyan Gao, Dandan Wang, Zhi-Hao |
author_sort | Li, Yiyi |
collection | PubMed |
description | Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presence and activity of BDNF indicate its potential role in the pathogenesis, progression and treatment of both neurological and psychiatric disorders. This review is to provide a comprehensive assessment of the current knowledge and future directions in BDNF-associated research in the central nervous system (CNS), with an emphasis on the physiological and pathological functions of BDNF as well as its potential treatment effects in CNS diseases, including depression, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebral ischemic stroke. |
format | Online Article Text |
id | pubmed-9493475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94934752022-09-23 The role of brain derived neurotrophic factor in central nervous system Li, Yiyi Li, Fang Qin, Dongdong Chen, Hongyu Wang, Jianhao Wang, Jiabei Song, Shafei Wang, Chao Wang, Yamei Liu, Songyan Gao, Dandan Wang, Zhi-Hao Front Aging Neurosci Aging Neuroscience Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presence and activity of BDNF indicate its potential role in the pathogenesis, progression and treatment of both neurological and psychiatric disorders. This review is to provide a comprehensive assessment of the current knowledge and future directions in BDNF-associated research in the central nervous system (CNS), with an emphasis on the physiological and pathological functions of BDNF as well as its potential treatment effects in CNS diseases, including depression, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebral ischemic stroke. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493475/ /pubmed/36158555 http://dx.doi.org/10.3389/fnagi.2022.986443 Text en Copyright © 2022 Li, Li, Qin, Chen, Wang, Wang, Song, Wang, Wang, Liu, Gao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Li, Yiyi Li, Fang Qin, Dongdong Chen, Hongyu Wang, Jianhao Wang, Jiabei Song, Shafei Wang, Chao Wang, Yamei Liu, Songyan Gao, Dandan Wang, Zhi-Hao The role of brain derived neurotrophic factor in central nervous system |
title | The role of brain derived neurotrophic factor in central nervous system |
title_full | The role of brain derived neurotrophic factor in central nervous system |
title_fullStr | The role of brain derived neurotrophic factor in central nervous system |
title_full_unstemmed | The role of brain derived neurotrophic factor in central nervous system |
title_short | The role of brain derived neurotrophic factor in central nervous system |
title_sort | role of brain derived neurotrophic factor in central nervous system |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493475/ https://www.ncbi.nlm.nih.gov/pubmed/36158555 http://dx.doi.org/10.3389/fnagi.2022.986443 |
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