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Perspective on direction of control: Cellular metabolism and macrophage polarization
Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493491/ https://www.ncbi.nlm.nih.gov/pubmed/36159824 http://dx.doi.org/10.3389/fimmu.2022.918747 |
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author | Thibaut, Ronan Orliaguet, Lucie Ejlalmanesh, Tina Venteclef, Nicolas Alzaid, Fawaz |
author_facet | Thibaut, Ronan Orliaguet, Lucie Ejlalmanesh, Tina Venteclef, Nicolas Alzaid, Fawaz |
author_sort | Thibaut, Ronan |
collection | PubMed |
description | Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a key factor influencing macrophage function. While pro-inflammatory macrophages mostly use glycolysis to meet their energetic needs, anti-inflammatory macrophages heavily rely on mitochondrial respiration. The relationship between macrophage phenotype and macrophage metabolism is well established, however its precise directionality is still under question. Indeed, whether cellular metabolism per se influences macrophage phenotype or whether macrophage polarization dictates metabolic activity is an area of active research. In this short perspective article, we sought to shed light on this area. By modulating several metabolic pathways in bone marrow-derived macrophages, we show that disruption of cellular metabolism does per se influence cytokine secretion profile and expression of key inflammatory genes. Only some pathways seem to be involved in these processes, highlighting the need for specific metabolic functions in the regulation of macrophage phenotype. We thus demonstrate that the intact nature of cellular metabolism influences macrophage phenotype and function, addressing the directionality between these two aspects of macrophage biology. |
format | Online Article Text |
id | pubmed-9493491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94934912022-09-23 Perspective on direction of control: Cellular metabolism and macrophage polarization Thibaut, Ronan Orliaguet, Lucie Ejlalmanesh, Tina Venteclef, Nicolas Alzaid, Fawaz Front Immunol Immunology Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a key factor influencing macrophage function. While pro-inflammatory macrophages mostly use glycolysis to meet their energetic needs, anti-inflammatory macrophages heavily rely on mitochondrial respiration. The relationship between macrophage phenotype and macrophage metabolism is well established, however its precise directionality is still under question. Indeed, whether cellular metabolism per se influences macrophage phenotype or whether macrophage polarization dictates metabolic activity is an area of active research. In this short perspective article, we sought to shed light on this area. By modulating several metabolic pathways in bone marrow-derived macrophages, we show that disruption of cellular metabolism does per se influence cytokine secretion profile and expression of key inflammatory genes. Only some pathways seem to be involved in these processes, highlighting the need for specific metabolic functions in the regulation of macrophage phenotype. We thus demonstrate that the intact nature of cellular metabolism influences macrophage phenotype and function, addressing the directionality between these two aspects of macrophage biology. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493491/ /pubmed/36159824 http://dx.doi.org/10.3389/fimmu.2022.918747 Text en Copyright © 2022 Thibaut, Orliaguet, Ejlalmanesh, Venteclef and Alzaid https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Thibaut, Ronan Orliaguet, Lucie Ejlalmanesh, Tina Venteclef, Nicolas Alzaid, Fawaz Perspective on direction of control: Cellular metabolism and macrophage polarization |
title | Perspective on direction of control: Cellular metabolism and macrophage polarization |
title_full | Perspective on direction of control: Cellular metabolism and macrophage polarization |
title_fullStr | Perspective on direction of control: Cellular metabolism and macrophage polarization |
title_full_unstemmed | Perspective on direction of control: Cellular metabolism and macrophage polarization |
title_short | Perspective on direction of control: Cellular metabolism and macrophage polarization |
title_sort | perspective on direction of control: cellular metabolism and macrophage polarization |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493491/ https://www.ncbi.nlm.nih.gov/pubmed/36159824 http://dx.doi.org/10.3389/fimmu.2022.918747 |
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