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Perspective on direction of control: Cellular metabolism and macrophage polarization

Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a...

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Autores principales: Thibaut, Ronan, Orliaguet, Lucie, Ejlalmanesh, Tina, Venteclef, Nicolas, Alzaid, Fawaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493491/
https://www.ncbi.nlm.nih.gov/pubmed/36159824
http://dx.doi.org/10.3389/fimmu.2022.918747
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author Thibaut, Ronan
Orliaguet, Lucie
Ejlalmanesh, Tina
Venteclef, Nicolas
Alzaid, Fawaz
author_facet Thibaut, Ronan
Orliaguet, Lucie
Ejlalmanesh, Tina
Venteclef, Nicolas
Alzaid, Fawaz
author_sort Thibaut, Ronan
collection PubMed
description Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a key factor influencing macrophage function. While pro-inflammatory macrophages mostly use glycolysis to meet their energetic needs, anti-inflammatory macrophages heavily rely on mitochondrial respiration. The relationship between macrophage phenotype and macrophage metabolism is well established, however its precise directionality is still under question. Indeed, whether cellular metabolism per se influences macrophage phenotype or whether macrophage polarization dictates metabolic activity is an area of active research. In this short perspective article, we sought to shed light on this area. By modulating several metabolic pathways in bone marrow-derived macrophages, we show that disruption of cellular metabolism does per se influence cytokine secretion profile and expression of key inflammatory genes. Only some pathways seem to be involved in these processes, highlighting the need for specific metabolic functions in the regulation of macrophage phenotype. We thus demonstrate that the intact nature of cellular metabolism influences macrophage phenotype and function, addressing the directionality between these two aspects of macrophage biology.
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spelling pubmed-94934912022-09-23 Perspective on direction of control: Cellular metabolism and macrophage polarization Thibaut, Ronan Orliaguet, Lucie Ejlalmanesh, Tina Venteclef, Nicolas Alzaid, Fawaz Front Immunol Immunology Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a key factor influencing macrophage function. While pro-inflammatory macrophages mostly use glycolysis to meet their energetic needs, anti-inflammatory macrophages heavily rely on mitochondrial respiration. The relationship between macrophage phenotype and macrophage metabolism is well established, however its precise directionality is still under question. Indeed, whether cellular metabolism per se influences macrophage phenotype or whether macrophage polarization dictates metabolic activity is an area of active research. In this short perspective article, we sought to shed light on this area. By modulating several metabolic pathways in bone marrow-derived macrophages, we show that disruption of cellular metabolism does per se influence cytokine secretion profile and expression of key inflammatory genes. Only some pathways seem to be involved in these processes, highlighting the need for specific metabolic functions in the regulation of macrophage phenotype. We thus demonstrate that the intact nature of cellular metabolism influences macrophage phenotype and function, addressing the directionality between these two aspects of macrophage biology. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493491/ /pubmed/36159824 http://dx.doi.org/10.3389/fimmu.2022.918747 Text en Copyright © 2022 Thibaut, Orliaguet, Ejlalmanesh, Venteclef and Alzaid https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Thibaut, Ronan
Orliaguet, Lucie
Ejlalmanesh, Tina
Venteclef, Nicolas
Alzaid, Fawaz
Perspective on direction of control: Cellular metabolism and macrophage polarization
title Perspective on direction of control: Cellular metabolism and macrophage polarization
title_full Perspective on direction of control: Cellular metabolism and macrophage polarization
title_fullStr Perspective on direction of control: Cellular metabolism and macrophage polarization
title_full_unstemmed Perspective on direction of control: Cellular metabolism and macrophage polarization
title_short Perspective on direction of control: Cellular metabolism and macrophage polarization
title_sort perspective on direction of control: cellular metabolism and macrophage polarization
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493491/
https://www.ncbi.nlm.nih.gov/pubmed/36159824
http://dx.doi.org/10.3389/fimmu.2022.918747
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