HepT1-derived murine models of high-risk hepatoblastoma display vascular invasion, metastasis, and circulating tumor cells

Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models that show high-risk features including multifocal t...

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Detalles Bibliográficos
Autores principales: Woodfield, Sarah E., Mistretta, Brandon J., Patel, Roma H., Ibarra, Aryana M., Fisher, Kevin E., Sarabia, Stephen F., Gandhi, Ilavarasi, Reuther, Jacquelyn, Starosolski, Zbigniew, Badachhape, Andrew, Epps, Jessica, Zorman, Barry, Shah, Aayushi P., Larson, Samuel R., Srivastava, Rohit K., Shi, Yan, Espinoza, Andres F., Govindu, Saiabhiroop R., Whitlock, Richard S., Holloway, Kimberly, Roy, Angshumoy, Sumazin, Pavel, Ghaghada, Ketan B., Lopez-Terrada, Dolores, Gunaratne, Preethi H., Vasudevan, Sanjeev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493725/
https://www.ncbi.nlm.nih.gov/pubmed/35451474
http://dx.doi.org/10.1242/bio.058973

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