Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis

BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disease primarily characterized by cartilage destruction. The aim of this study was to investigate the role, molecular characteristics and potential therapeutic target of chondrocyte ferroptosis in the pathogenesis of OA. METHODS:...

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Detalles Bibliográficos
Autores principales: Lv, Zhongyang, Han, Jie, Li, Jiawei, Guo, Hu, Fei, Yuxiang, Sun, Ziying, Dong, Jian, Wang, Maochun, Fan, Chunmei, Li, Weitong, Xie, Ya, Sun, Wei, Chen, Jiaqi, Liu, Yuan, Chen, Fufei, Liu, Zizheng, Liu, Anlong, Wu, Rui, Xu, Xingquan, Yan, Wenjin, Jiang, Qing, Ikegawa, Shiro, Chen, Xiao, Shi, Dongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494174/
https://www.ncbi.nlm.nih.gov/pubmed/36137413
http://dx.doi.org/10.1016/j.ebiom.2022.104258

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