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In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M(Pro) inhibitors

An essential target for COVID-19 is the main protease of SARS-CoV-2 (M(pro)). With the objective of targeting this receptor, a novel set of pyrido[1,2-a]pyrrolo[2,3-d]pyrimidines with terminal carboxamide fragments was designed, synthesized, and considered as an initial motif for the creation of eff...

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Detalles Bibliográficos
Autores principales:	Aljuhani, Ateyatallah, Ahmed, Hany E. A., Ihmaid, Saleh K., Omar, Abdelsattar M., Althagfan, Sultan S., Alahmadi, Yaser M., Ahmad, Iqrar, Patel, Harun, Ahmed, Sahar, Almikhlafi, Mohannad A., El-Agrody, Ahmed M., Zayed, Mohamed F., Turkistani, Safaa Abdulrahman, Abulkhair, Shorouk H., Almaghrabi, Mohammed, Salama, Samir A., Al-Karmalawy, Ahmed A., Abulkhair, Hamada S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494209/ https://www.ncbi.nlm.nih.gov/pubmed/36320844 http://dx.doi.org/10.1039/d2ra04015h

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