Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming

Endothelial cell (EC) metabolism has emerged as a driver of angiogenesis. While hypoxia inactivates the oxygen sensors prolyl-4 hydroxylase domain-containing proteins 1–3 (PHD1-3) and stimulates angiogenesis, the effects of PHDs on EC functions remain poorly defined. Here, we investigated the impact...

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Detalles Bibliográficos
Autores principales: Tiwari, Ratnakar, Bommi, Prashant V., Gao, Peng, Schipma, Matthew J., Zhou, Yalu, Quaggin, Susan E., Chandel, Navdeep S., Kapitsinou, Pinelopi P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494243/
https://www.ncbi.nlm.nih.gov/pubmed/36157579
http://dx.doi.org/10.1016/j.isci.2022.105086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494243/
https://www.ncbi.nlm.nih.gov/pubmed/36157579
http://dx.doi.org/10.1016/j.isci.2022.105086

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