Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis

We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19) pathogenesis in a mouse model. To test relevance to human disease, we used electronic health record databases and determined that patients on dupilumab (anti-interleukin [IL]-4R monoclonal antibody that blocks IL-1...

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Autores principales: Donlan, Alexandra N, Mallawaarachchi, Indika, Sasson, Jennifer M, Preissner, Robert, Loomba, Johanna J, Petri, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494491/
https://www.ncbi.nlm.nih.gov/pubmed/36104868
http://dx.doi.org/10.1093/cid/ciac745
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author Donlan, Alexandra N
Mallawaarachchi, Indika
Sasson, Jennifer M
Preissner, Robert
Loomba, Johanna J
Petri, William A
author_facet Donlan, Alexandra N
Mallawaarachchi, Indika
Sasson, Jennifer M
Preissner, Robert
Loomba, Johanna J
Petri, William A
author_sort Donlan, Alexandra N
collection PubMed
description We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19) pathogenesis in a mouse model. To test relevance to human disease, we used electronic health record databases and determined that patients on dupilumab (anti-interleukin [IL]-4R monoclonal antibody that blocks IL-13 and IL-4 signaling) at the time of COVID-19 infection had lower mortality.
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spelling pubmed-94944912022-09-27 Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis Donlan, Alexandra N Mallawaarachchi, Indika Sasson, Jennifer M Preissner, Robert Loomba, Johanna J Petri, William A Clin Infect Dis Brief Report We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19) pathogenesis in a mouse model. To test relevance to human disease, we used electronic health record databases and determined that patients on dupilumab (anti-interleukin [IL]-4R monoclonal antibody that blocks IL-13 and IL-4 signaling) at the time of COVID-19 infection had lower mortality. Oxford University Press 2022-09-15 /pmc/articles/PMC9494491/ /pubmed/36104868 http://dx.doi.org/10.1093/cid/ciac745 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Donlan, Alexandra N
Mallawaarachchi, Indika
Sasson, Jennifer M
Preissner, Robert
Loomba, Johanna J
Petri, William A
Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis
title Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis
title_full Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis
title_fullStr Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis
title_full_unstemmed Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis
title_short Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis
title_sort dupilumab use is associated with protection from coronavirus disease 2019 mortality: a retrospective analysis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494491/
https://www.ncbi.nlm.nih.gov/pubmed/36104868
http://dx.doi.org/10.1093/cid/ciac745
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