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Combination of gait speed and grip strength to predict cognitive decline and dementia
INTRODUCTION: To determine whether slowed gait and weakened grip strength independently, or together, better identify risk of cognitive decline or dementia. METHODS: Time to walk 3 meters and grip strength were measured in a randomized placebo‐controlled clinical trial involving community‐dwelling,...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494608/ https://www.ncbi.nlm.nih.gov/pubmed/36187193 http://dx.doi.org/10.1002/dad2.12353 |
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author | Orchard, Suzanne G. Polekhina, Galina Ryan, Joanne Shah, Raj C. Storey, Elsdon Chong, Trevor T.‐J. Lockery, Jessica E. Ward, Stephanie A. Wolfe, Rory Nelson, Mark R. Reid, Christopher M. Murray, Anne M. Espinoza, Sara E. Newman, Anne B. McNeil, John J. Collyer, Taya A. Callisaya, Michele L. Woods, Robyn L. |
author_facet | Orchard, Suzanne G. Polekhina, Galina Ryan, Joanne Shah, Raj C. Storey, Elsdon Chong, Trevor T.‐J. Lockery, Jessica E. Ward, Stephanie A. Wolfe, Rory Nelson, Mark R. Reid, Christopher M. Murray, Anne M. Espinoza, Sara E. Newman, Anne B. McNeil, John J. Collyer, Taya A. Callisaya, Michele L. Woods, Robyn L. |
author_sort | Orchard, Suzanne G. |
collection | PubMed |
description | INTRODUCTION: To determine whether slowed gait and weakened grip strength independently, or together, better identify risk of cognitive decline or dementia. METHODS: Time to walk 3 meters and grip strength were measured in a randomized placebo‐controlled clinical trial involving community‐dwelling, initially cognitively healthy older adults (N = 19,114). RESULTS: Over a median 4.7 years follow‐up, slow gait and weak grip strength at baseline were independently associated with risk of incident dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI]: 1.19–1.73; and 1.24, 95% CI: 1.04–1.50, respectively) and cognitive decline (HR = 1.38, 95% CI: 1.26–1.51; and 1.04, 95% CI: 0.95–1.14, respectively) and when combined, were associated with 79% and 43% increase in risk of dementia and cognitive decline, respectively. Annual declines in gait and in grip over time showed similar results. DISCUSSION: Gait speed and grip strength are low‐cost markers that may be useful in the clinical setting to help identify and manage individuals at greater risk, or with early signs, of dementia, particularly when measured together. HIGHLIGHTS: Grip strength and gait speed are effective predictors and markers of dementia. Dementia risk is greater than cognitive decline risk with declines in gait or grip. Decline in gait speed, more so than in grip strength, predicts greater dementia risk. Greater risk prediction results from combining grip strength and gait speed. |
format | Online Article Text |
id | pubmed-9494608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94946082022-09-30 Combination of gait speed and grip strength to predict cognitive decline and dementia Orchard, Suzanne G. Polekhina, Galina Ryan, Joanne Shah, Raj C. Storey, Elsdon Chong, Trevor T.‐J. Lockery, Jessica E. Ward, Stephanie A. Wolfe, Rory Nelson, Mark R. Reid, Christopher M. Murray, Anne M. Espinoza, Sara E. Newman, Anne B. McNeil, John J. Collyer, Taya A. Callisaya, Michele L. Woods, Robyn L. Alzheimers Dement (Amst) Article INTRODUCTION: To determine whether slowed gait and weakened grip strength independently, or together, better identify risk of cognitive decline or dementia. METHODS: Time to walk 3 meters and grip strength were measured in a randomized placebo‐controlled clinical trial involving community‐dwelling, initially cognitively healthy older adults (N = 19,114). RESULTS: Over a median 4.7 years follow‐up, slow gait and weak grip strength at baseline were independently associated with risk of incident dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI]: 1.19–1.73; and 1.24, 95% CI: 1.04–1.50, respectively) and cognitive decline (HR = 1.38, 95% CI: 1.26–1.51; and 1.04, 95% CI: 0.95–1.14, respectively) and when combined, were associated with 79% and 43% increase in risk of dementia and cognitive decline, respectively. Annual declines in gait and in grip over time showed similar results. DISCUSSION: Gait speed and grip strength are low‐cost markers that may be useful in the clinical setting to help identify and manage individuals at greater risk, or with early signs, of dementia, particularly when measured together. HIGHLIGHTS: Grip strength and gait speed are effective predictors and markers of dementia. Dementia risk is greater than cognitive decline risk with declines in gait or grip. Decline in gait speed, more so than in grip strength, predicts greater dementia risk. Greater risk prediction results from combining grip strength and gait speed. John Wiley and Sons Inc. 2022-09-22 /pmc/articles/PMC9494608/ /pubmed/36187193 http://dx.doi.org/10.1002/dad2.12353 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Article Orchard, Suzanne G. Polekhina, Galina Ryan, Joanne Shah, Raj C. Storey, Elsdon Chong, Trevor T.‐J. Lockery, Jessica E. Ward, Stephanie A. Wolfe, Rory Nelson, Mark R. Reid, Christopher M. Murray, Anne M. Espinoza, Sara E. Newman, Anne B. McNeil, John J. Collyer, Taya A. Callisaya, Michele L. Woods, Robyn L. Combination of gait speed and grip strength to predict cognitive decline and dementia |
title | Combination of gait speed and grip strength to predict cognitive decline and dementia |
title_full | Combination of gait speed and grip strength to predict cognitive decline and dementia |
title_fullStr | Combination of gait speed and grip strength to predict cognitive decline and dementia |
title_full_unstemmed | Combination of gait speed and grip strength to predict cognitive decline and dementia |
title_short | Combination of gait speed and grip strength to predict cognitive decline and dementia |
title_sort | combination of gait speed and grip strength to predict cognitive decline and dementia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494608/ https://www.ncbi.nlm.nih.gov/pubmed/36187193 http://dx.doi.org/10.1002/dad2.12353 |
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