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Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases

[Image: see text] Janus kinases (JAKs) are nonreceptor protein tyrosine kinases that play a role in a broad range of cell signaling. JAK2 and JAK3 have been involved in the pathogenesis of common lymphoid-derived diseases and leukemia cancer. Thus, inhibition of both JAK2 and JAK3 can be a potent st...

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Detalles Bibliográficos
Autores principales:	Sanachai, Kamonpan, Mahalapbutr, Panupong, Hengphasatporn, Kowit, Shigeta, Yasuteru, Seetaha, Supaphorn, Tabtimmai, Lueacha, Langer, Thierry, Wolschann, Peter, Kittikool, Tanakorn, Yotphan, Sirilata, Choowongkomon, Kiattawee, Rungrotmongkol, Thanyada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494641/ https://www.ncbi.nlm.nih.gov/pubmed/36157769 http://dx.doi.org/10.1021/acsomega.2c04535

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