Cargando…

Discovery of JAK2/3 Inhibitors from Quinoxalinone-Containing Compounds

[Image: see text] Janus kinases (JAKs) are involved in a wide variety of cell signaling associated with T-cell and B-cell mediated diseases. The pathogenesis of common lymphoid-derived diseases and leukemia cancer has been implicated in JAK2 and JAK3. Therefore, to decrease the risk of these disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanachai, Kamonpan, Mahalapbutr, Panupong, Tabtimmai, Lueacha, Seetaha, Supaphorn, Kittikool, Tanakorn, Yotphan, Sirilata, Choowongkomon, Kiattawee, Rungrotmongkol, Thanyada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494680/ https://www.ncbi.nlm.nih.gov/pubmed/36157733 http://dx.doi.org/10.1021/acsomega.2c04769

Ejemplares similares

Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases
por: Sanachai, Kamonpan, et al.
Publicado: (2022)

In Silico and In Vitro Study of Janus Kinases Inhibitors from Naphthoquinones
por: Sanachai, Kamonpan, et al.
Publicado: (2023)

Quinoxalinones as A Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights
por: Suriya, Utid, et al.
Publicado: (2022)

Identification of Vinyl Sulfone Derivatives as EGFR Tyrosine Kinase Inhibitor: In Vitro and In Silico Studies
por: Aiebchun, Thitinan, et al.
Publicado: (2021)

Biological Evaluation and Molecular Dynamics Simulation of Chalcone Derivatives as Epidermal Growth Factor-Tyrosine Kinase Inhibitors
por: Sangpheak, Kanyani, et al.
Publicado: (2019)

Insights into the Binding Recognition and Susceptibility of Tofacitinib toward Janus Kinases
por: Sanachai, Kamonpan, et al.
Publicado: (2020)

Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia
por: Choengpanya, Khuanjarat, et al.
Publicado: (2021)

Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms
por: Seetaha, Supaphorn, et al.
Publicado: (2020)

Synchrotron Fourier Transform Infrared Microscopy Spectra in Cellular Effects of Janus Kinase Inhibitors on Myelofibrosis Cancer Cells
por: Siriwaseree, Jeeraprapa, et al.
Publicado: (2022)

Computational study on peptidomimetic inhibitors against SARS-CoV-2 main protease
por: Somboon, Tuanjai, et al.
Publicado: (2021)

Discovery of Novel EGFR Inhibitor Targeting Wild-Type and Mutant Forms of EGFR: In Silico and In Vitro Study
por: Todsaporn, Duangjai, et al.
Publicado: (2023)

Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors
por: Hengphasatporn, Kowit, et al.
Publicado: (2023)

Structural analysis of cannabinoids against EGFR-TK leads a novel target against EGFR-driven cell lines
por: Lamtha, Thomanai, et al.
Publicado: (2022)

Structural insight into the recognition of S-adenosyl-L-homocysteine and sinefungin in SARS-CoV-2 Nsp16/Nsp10 RNA cap 2′-O-Methyltransferase
por: Mahalapbutr, Panupong, et al.
Publicado: (2020)

Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site
por: Suriya, Utid, et al.
Publicado: (2022)

Computational Screening of Newly Designed Compounds against Coxsackievirus A16 and Enterovirus A71
por: Sripattaraphan, Amita, et al.
Publicado: (2022)

Two Flavonoid-Based Compounds from Murraya paniculata as Novel Human Carbonic Anhydrase Isozyme II Inhibitors Detected by a Resazurin Yeast-Based Assay
por: Sangkaew, Anyaporn, et al.
Publicado: (2020)

Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations
por: Mahalapbutr, Panupong, et al.
Publicado: (2019)

Pharmacogenetics and Precision Medicine Approaches for the Improvement of COVID-19 Therapies
por: Biswas, Mohitosh, et al.
Publicado: (2022)

Pyrazolones Potentiate Colistin Activity against MCR-1-Producing Resistant Bacteria: Computational and Microbiological Study
por: Hanpaibool, Chonnikan, et al.
Publicado: (2023)

A novel nanobody as therapeutics target for EGFR-positive colorectal cancer therapy: exploring the effects of the nanobody on SW480 cells using proteomics approach
por: Lamtha, Thomanai, et al.
Publicado: (2022)

Generation of a Single-Chain Variable Fragment Antibody against Feline Immunoglobulin G for Biosensor Applications
por: Rasri, Natchaya, et al.
Publicado: (2023)

In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases
por: Mee-udorn, Pitchayathida, et al.
Publicado: (2023)

The Effect of the EGFR - Targeting Compound 3-[(4-Phenylpyrimidin-2-yl) Amino] Benzene-1-Sulfonamide (13f) against Cholangiocarcinoma Cell Lines
por: Samatiwat, Papavee, et al.
Publicado: (2021)

Fisetin glycosides synthesized by cyclodextrin glycosyltransferase from Paenibacillus sp. RB01: characterization, molecular docking, and antioxidant activity
por: Lorthongpanich, Nattawadee, et al.
Publicado: (2022)

Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase
por: Ratanabunyong, Siriluk, et al.
Publicado: (2022)

Selection, alkaline phosphatase fusion, and application of single-chain variable fragment (scFv) specific to NT-proBNP as electrochemical immunosensor for heart failure
por: Wongjard, Sureeporn, et al.
Publicado: (2023)

Enhanced Solubility and Anticancer Potential of Mansonone G By β-Cyclodextrin-Based Host-Guest Complexation: A Computational and Experimental Study
por: Mahalapbutr, Panupong, et al.
Publicado: (2019)

Aurisin A Complexed with 2,6-Di-O-methyl-β-cyclodextrin Enhances Aqueous Solubility, Thermal Stability, and Antiproliferative Activity against Lung Cancer Cells
por: Charoenwongpaiboon, Thanapon, et al.
Publicado: (2022)

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies
por: Aman, Aamir, et al.
Publicado: (2023)

Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines
por: Sangpheak, Kanyani, et al.
Publicado: (2018)

Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein
por: Darai, Nitchakan, et al.
Publicado: (2022)

Discovery of Anilino-1,4-naphthoquinones as Potent EGFR Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Comprehensive Molecular Modeling
por: Mahalapbutr, Panupong, et al.
Publicado: (2022)

Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling
por: Leechaisit, Ronnakorn, et al.
Publicado: (2023)

Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition
por: Mahalapbutr, Panupong, et al.
Publicado: (2019)

Publisher Correction: Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition
por: Mahalapbutr, Panupong, et al.
Publicado: (2019)

Synthesis, HIV-1 RT inhibitory, antibacterial, antifungal and binding mode studies of some novel N-substituted 5-benzylidine-2,4-thiazolidinediones
por: Bahare, Radhe Shyam, et al.
Publicado: (2015)

Identification of repurposing therapeutics toward SARS-CoV-2 main protease by virtual screening
por: Sanachai, Kamonpan, et al.
Publicado: (2022)

Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics
por: Lin, Aye Chan Khine, et al.
Publicado: (2022)

Rhodium-catalyzed selenylation and sulfenylation of quinoxalinones ‘on water’
por: Lalji, Ram Sunil Kumar, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8kfeb7g7kr4rj33e9bdmfreuil