Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex

[Image: see text] Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally comprising binding partners WDR5, RbBP5, Ash2L,...

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Detalles Bibliográficos
Autores principales: Edwardes, Lucy V., Caswell, Sarah J., Giurrandino, Mariacarmela, Zhai, Xiang, Gohlke, Andrea, Kostomiris, Demetrios H., Pollard, Hannah K., Pflug, Alexander, Hamm, Gregory R., Jervis, Kate V., Clarkson, Paul N., Syson, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494746/
https://www.ncbi.nlm.nih.gov/pubmed/36070615
http://dx.doi.org/10.1021/acs.biochem.2c00385

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