Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive heterotopic ossification (HO) in soft tissues due to a heterozygous mutation of the ACVR1A gene (FOP-ACVR1A), which erroneously transduces the BMP signal by Activin-A. Although inflammation...

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Detalles Bibliográficos
Autores principales: Maekawa, Hirotsugu, Jin, Yonghui, Nishio, Megumi, Kawai, Shunsuke, Nagata, Sanae, Kamakura, Takeshi, Yoshitomi, Hiroyuki, Niwa, Akira, Saito, Megumu K., Matsuda, Shuichi, Toguchida, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494870/
https://www.ncbi.nlm.nih.gov/pubmed/36131296
http://dx.doi.org/10.1186/s13023-022-02506-3

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