Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport

BACKGROUND: The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated serum leptin. Considering that leptin must cross the blood–brain barrier (BBB) in...

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Detalles Bibliográficos
Autores principales: Shi, Yajuan, Kim, Hyosung, Hamann, Catherine A., Rhea, Elizabeth M., Brunger, Jonathan M., Lippmann, Ethan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494897/
https://www.ncbi.nlm.nih.gov/pubmed/36131285
http://dx.doi.org/10.1186/s12987-022-00375-3

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