In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii

The rapid worldwide spread of antimicrobial resistance highlights the significant need for the development of innovative treatments to fight multidrug-resistant bacteria. This study describes the potent antimicrobial activity of the novel peptide OMN6 against a wide array of drug-resistant Acinetoba...

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Autores principales: Michaeli, Janna, Mandel, Shira, Maximov, Shelly, Zazoun, Jonathan, Savoia, Paola, Kothari, Nimmi, Valmont, Thomas, Ferrari, Livia, Duncan, Leonard R., Hawser, Stephen, Cohen-Kutner, Moshe, Bachnoff, Niv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494975/
https://www.ncbi.nlm.nih.gov/pubmed/36139979
http://dx.doi.org/10.3390/antibiotics11091201
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author Michaeli, Janna
Mandel, Shira
Maximov, Shelly
Zazoun, Jonathan
Savoia, Paola
Kothari, Nimmi
Valmont, Thomas
Ferrari, Livia
Duncan, Leonard R.
Hawser, Stephen
Cohen-Kutner, Moshe
Bachnoff, Niv
author_facet Michaeli, Janna
Mandel, Shira
Maximov, Shelly
Zazoun, Jonathan
Savoia, Paola
Kothari, Nimmi
Valmont, Thomas
Ferrari, Livia
Duncan, Leonard R.
Hawser, Stephen
Cohen-Kutner, Moshe
Bachnoff, Niv
author_sort Michaeli, Janna
collection PubMed
description The rapid worldwide spread of antimicrobial resistance highlights the significant need for the development of innovative treatments to fight multidrug-resistant bacteria. This study describes the potent antimicrobial activity of the novel peptide OMN6 against a wide array of drug-resistant Acinetobacter baumannii clinical isolates. OMN6 prevented the growth of all tested isolates, regardless of any pre-existing resistance mechanisms. Moreover, in vitro serial-passaging studies demonstrated that no resistance developed against OMN6. Importantly, OMN6 was highly efficacious in treating animal models of lung and blood infections caused by multidrug-resistant A. baumannii. Taken together, these results point to OMN6 as a novel antimicrobial agent with the potential to treat life-threatening infections caused by multidrug-resistant A. baumannii avoiding resistance.
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spelling pubmed-94949752022-09-23 In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii Michaeli, Janna Mandel, Shira Maximov, Shelly Zazoun, Jonathan Savoia, Paola Kothari, Nimmi Valmont, Thomas Ferrari, Livia Duncan, Leonard R. Hawser, Stephen Cohen-Kutner, Moshe Bachnoff, Niv Antibiotics (Basel) Article The rapid worldwide spread of antimicrobial resistance highlights the significant need for the development of innovative treatments to fight multidrug-resistant bacteria. This study describes the potent antimicrobial activity of the novel peptide OMN6 against a wide array of drug-resistant Acinetobacter baumannii clinical isolates. OMN6 prevented the growth of all tested isolates, regardless of any pre-existing resistance mechanisms. Moreover, in vitro serial-passaging studies demonstrated that no resistance developed against OMN6. Importantly, OMN6 was highly efficacious in treating animal models of lung and blood infections caused by multidrug-resistant A. baumannii. Taken together, these results point to OMN6 as a novel antimicrobial agent with the potential to treat life-threatening infections caused by multidrug-resistant A. baumannii avoiding resistance. MDPI 2022-09-05 /pmc/articles/PMC9494975/ /pubmed/36139979 http://dx.doi.org/10.3390/antibiotics11091201 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michaeli, Janna
Mandel, Shira
Maximov, Shelly
Zazoun, Jonathan
Savoia, Paola
Kothari, Nimmi
Valmont, Thomas
Ferrari, Livia
Duncan, Leonard R.
Hawser, Stephen
Cohen-Kutner, Moshe
Bachnoff, Niv
In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii
title In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii
title_full In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii
title_fullStr In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii
title_full_unstemmed In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii
title_short In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii
title_sort in vitro and in vivo antimicrobial activity of the novel peptide omn6 against multidrug-resistant acinetobacter baumannii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494975/
https://www.ncbi.nlm.nih.gov/pubmed/36139979
http://dx.doi.org/10.3390/antibiotics11091201
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