Administering an Appeasing Substance to Improve Performance, Neuroendocrine Stress Response, and Health of Ruminants

SIMPLE SUMMARY: Stress is present in several management activities of beef and dairy cattle, leading to health and productive losses to the herd. Therefore, strategies are warranted to reduce any losses related to these stressful situations, and bovine appeasing substance (BAS) is arising as a potential technology in livestock production settings. Several peer-reviewed publications have evaluated BAS in different production settings, such as weaning, feedlot entry, castration, transport to the slaughterhouse, and pre-weaning dairy cattle. Altogether, performance, health, and carcass traits have been positively impacted by BAS administration, demonstrating the efficacy of this technology for ruminants. ABSTRACT: The present review demonstrates the main attributes of stress-related responses in ruminants, and the potential interaction with the immune system of the host is also presented, demonstrating that alternatives that reduce the response to stressful situations are warranted to maintain adequate health and performance of the herd. In this scenario, pheromones and their modes of action are presented, opening space to a recent technology being used for ruminants: bovine appeasing substance (BAS). This substance has been used in different species, such as swine, with positive behavioral, health, and performance results. So, its utilization in ruminants has been reported to improve performance and inflammatory-mediated responses, promoting the productivity and welfare of the livestock industry.