Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

Extracellular histones play a dual role—antimicrobial and cytotoxic—in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties. Broth microdilution assays indicated that histone H3 exhibi...

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Detalles Bibliográficos
Autores principales: Tanaka, Yuri, Yamanaka, Nanako, Koyano, Izumi, Hasunuma, Itaru, Kobayashi, Tetsuya, Kikuyama, Sakae, Iwamuro, Shawichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495139/
https://www.ncbi.nlm.nih.gov/pubmed/36140018
http://dx.doi.org/10.3390/antibiotics11091240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495139/
https://www.ncbi.nlm.nih.gov/pubmed/36140018
http://dx.doi.org/10.3390/antibiotics11091240

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