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Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections

Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking effic...

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Autores principales: Zarenezhad, Elham, Abdulabbas, Hussein T., Marzi, Mahrokh, Ghazy, Esraa, Ekrahi, Mohammad, Pezeshki, Babak, Ghasemian, Abdolmajid, Moawad, Amira A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495148/
https://www.ncbi.nlm.nih.gov/pubmed/36139986
http://dx.doi.org/10.3390/antibiotics11091208
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author Zarenezhad, Elham
Abdulabbas, Hussein T.
Marzi, Mahrokh
Ghazy, Esraa
Ekrahi, Mohammad
Pezeshki, Babak
Ghasemian, Abdolmajid
Moawad, Amira A.
author_facet Zarenezhad, Elham
Abdulabbas, Hussein T.
Marzi, Mahrokh
Ghazy, Esraa
Ekrahi, Mohammad
Pezeshki, Babak
Ghasemian, Abdolmajid
Moawad, Amira A.
author_sort Zarenezhad, Elham
collection PubMed
description Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic and therapeutic cheap agents to various aspects of biomedical sciences. Their antibacterial effects are exerted via the disruption of the cell membrane, the deformation of proteins, and the inhibition of DNA replication. NiNPs proper traits include high-level chemical stability and binding affinity, ferromagnetic properties, ecofriendliness, and cost-effectiveness. They have outlined pleomorphic and cubic structures. The combined application of NiNPs with CuO, ZnO, and CdO has enhanced their anti-MRSA effects. The NiNPs at an approximate size of around 50 nm have exerted efficient anti-MRSA effects, particularly at higher concentrations. NiNPs have conferred higher antibacterial effects against MRSA than other nosocomial bacterial pathogens. The application of green synthesis and low-cost materials such as albumin and chitosan enhance the efficacy of NPs for therapeutic purposes.
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spelling pubmed-94951482022-09-23 Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections Zarenezhad, Elham Abdulabbas, Hussein T. Marzi, Mahrokh Ghazy, Esraa Ekrahi, Mohammad Pezeshki, Babak Ghasemian, Abdolmajid Moawad, Amira A. Antibiotics (Basel) Review Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic and therapeutic cheap agents to various aspects of biomedical sciences. Their antibacterial effects are exerted via the disruption of the cell membrane, the deformation of proteins, and the inhibition of DNA replication. NiNPs proper traits include high-level chemical stability and binding affinity, ferromagnetic properties, ecofriendliness, and cost-effectiveness. They have outlined pleomorphic and cubic structures. The combined application of NiNPs with CuO, ZnO, and CdO has enhanced their anti-MRSA effects. The NiNPs at an approximate size of around 50 nm have exerted efficient anti-MRSA effects, particularly at higher concentrations. NiNPs have conferred higher antibacterial effects against MRSA than other nosocomial bacterial pathogens. The application of green synthesis and low-cost materials such as albumin and chitosan enhance the efficacy of NPs for therapeutic purposes. MDPI 2022-09-07 /pmc/articles/PMC9495148/ /pubmed/36139986 http://dx.doi.org/10.3390/antibiotics11091208 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zarenezhad, Elham
Abdulabbas, Hussein T.
Marzi, Mahrokh
Ghazy, Esraa
Ekrahi, Mohammad
Pezeshki, Babak
Ghasemian, Abdolmajid
Moawad, Amira A.
Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections
title Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections
title_full Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections
title_fullStr Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections
title_full_unstemmed Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections
title_short Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections
title_sort nickel nanoparticles: applications and antimicrobial role against methicillin-resistant staphylococcus aureus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495148/
https://www.ncbi.nlm.nih.gov/pubmed/36139986
http://dx.doi.org/10.3390/antibiotics11091208
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