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Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective

Streptococcus agalactiae is a well-known pathogen in humans and food-producing animals. Therefore, this bacterium is a paradigmatic example of a pathogen to be controlled by a One Health approach. Indeed, the zoonotic and reverse-zoonotic potential of the bacteria, the prevalence of Group B Streptoc...

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Autores principales: Meroni, Gabriele, Sora, Valerio M., Martino, Piera Anna, Sbernini, Alice, Laterza, Giulia, Zaghen, Francesca, Soggiu, Alessio, Zecconi, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495180/
https://www.ncbi.nlm.nih.gov/pubmed/36140016
http://dx.doi.org/10.3390/antibiotics11091236
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author Meroni, Gabriele
Sora, Valerio M.
Martino, Piera Anna
Sbernini, Alice
Laterza, Giulia
Zaghen, Francesca
Soggiu, Alessio
Zecconi, Alfonso
author_facet Meroni, Gabriele
Sora, Valerio M.
Martino, Piera Anna
Sbernini, Alice
Laterza, Giulia
Zaghen, Francesca
Soggiu, Alessio
Zecconi, Alfonso
author_sort Meroni, Gabriele
collection PubMed
description Streptococcus agalactiae is a well-known pathogen in humans and food-producing animals. Therefore, this bacterium is a paradigmatic example of a pathogen to be controlled by a One Health approach. Indeed, the zoonotic and reverse-zoonotic potential of the bacteria, the prevalence of Group B Streptococci (GBS) diseases in both human and animal domains, and the threatening global situation on GBS antibiotic resistance make these bacteria an important target for control programs. An epidemiological analysis using a public database containing sequences of S. agalactiae from all over the world was conducted to evaluate the frequency and evolution of antibiotic resistance genes in those isolates. The database we considered (NCBI pathogen detection isolate browser—NPDIB) is maintained on a voluntary basis. Therefore, it does not follow strict epidemiological criteria. However, it may be considered representative of the bacterial population related to human diseases. The results showed that the number of reported sequences increased largely in the last four years, and about 50% are of European origin. The frequency data and the cluster analysis showed that the AMR genes increased in frequency in recent years and suggest the importance of verifying the application of prudent protocols for antimicrobials in areas with an increasing frequency of GBS infections both in human and veterinary medicine.
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spelling pubmed-94951802022-09-23 Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective Meroni, Gabriele Sora, Valerio M. Martino, Piera Anna Sbernini, Alice Laterza, Giulia Zaghen, Francesca Soggiu, Alessio Zecconi, Alfonso Antibiotics (Basel) Article Streptococcus agalactiae is a well-known pathogen in humans and food-producing animals. Therefore, this bacterium is a paradigmatic example of a pathogen to be controlled by a One Health approach. Indeed, the zoonotic and reverse-zoonotic potential of the bacteria, the prevalence of Group B Streptococci (GBS) diseases in both human and animal domains, and the threatening global situation on GBS antibiotic resistance make these bacteria an important target for control programs. An epidemiological analysis using a public database containing sequences of S. agalactiae from all over the world was conducted to evaluate the frequency and evolution of antibiotic resistance genes in those isolates. The database we considered (NCBI pathogen detection isolate browser—NPDIB) is maintained on a voluntary basis. Therefore, it does not follow strict epidemiological criteria. However, it may be considered representative of the bacterial population related to human diseases. The results showed that the number of reported sequences increased largely in the last four years, and about 50% are of European origin. The frequency data and the cluster analysis showed that the AMR genes increased in frequency in recent years and suggest the importance of verifying the application of prudent protocols for antimicrobials in areas with an increasing frequency of GBS infections both in human and veterinary medicine. MDPI 2022-09-12 /pmc/articles/PMC9495180/ /pubmed/36140016 http://dx.doi.org/10.3390/antibiotics11091236 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meroni, Gabriele
Sora, Valerio M.
Martino, Piera Anna
Sbernini, Alice
Laterza, Giulia
Zaghen, Francesca
Soggiu, Alessio
Zecconi, Alfonso
Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective
title Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective
title_full Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective
title_fullStr Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective
title_full_unstemmed Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective
title_short Epidemiology of Antimicrobial Resistance Genes in Streptococcus agalactiae Sequences from a Public Database in a One Health Perspective
title_sort epidemiology of antimicrobial resistance genes in streptococcus agalactiae sequences from a public database in a one health perspective
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495180/
https://www.ncbi.nlm.nih.gov/pubmed/36140016
http://dx.doi.org/10.3390/antibiotics11091236
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