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Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds

Candida albicans is an endogenous opportunistic pathogenic fungus that is harmless when the host system remains stable. However, C. albicans could seriously threaten human life and health when the body’s immune function declines or the normal flora is out of balance. Due to the increasing resistance...

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Autores principales: Li, Honghua, Yang, Jinpeng, Zhang, Xinwan, Xu, Xiuli, Song, Fuhang, Li, Hehe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495215/
https://www.ncbi.nlm.nih.gov/pubmed/36140017
http://dx.doi.org/10.3390/antibiotics11091238
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author Li, Honghua
Yang, Jinpeng
Zhang, Xinwan
Xu, Xiuli
Song, Fuhang
Li, Hehe
author_facet Li, Honghua
Yang, Jinpeng
Zhang, Xinwan
Xu, Xiuli
Song, Fuhang
Li, Hehe
author_sort Li, Honghua
collection PubMed
description Candida albicans is an endogenous opportunistic pathogenic fungus that is harmless when the host system remains stable. However, C. albicans could seriously threaten human life and health when the body’s immune function declines or the normal flora is out of balance. Due to the increasing resistance of candidiasis to existing drugs, it is important to find new strategies to help treat this type of systemic fungal disease. Biological control is considered as a promising strategy which is more friendly and safer. In this review, we compare the bacteriostatic behavior of different antagonistic microorganisms (bacteria and fungi) against C. albicans. In addition, natural products with unique structures have attracted researchers’ attention. Therefore, the bioactive nature products produced by different microorganisms and their possible inhibitory mechanisms are also reviewed. The application of biological control strategies and the discovery of new compounds with antifungal activity will reduce the resistance of C. albicans, thereby promoting the development of novel diverse antifungal drugs.
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spelling pubmed-94952152022-09-23 Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds Li, Honghua Yang, Jinpeng Zhang, Xinwan Xu, Xiuli Song, Fuhang Li, Hehe Antibiotics (Basel) Review Candida albicans is an endogenous opportunistic pathogenic fungus that is harmless when the host system remains stable. However, C. albicans could seriously threaten human life and health when the body’s immune function declines or the normal flora is out of balance. Due to the increasing resistance of candidiasis to existing drugs, it is important to find new strategies to help treat this type of systemic fungal disease. Biological control is considered as a promising strategy which is more friendly and safer. In this review, we compare the bacteriostatic behavior of different antagonistic microorganisms (bacteria and fungi) against C. albicans. In addition, natural products with unique structures have attracted researchers’ attention. Therefore, the bioactive nature products produced by different microorganisms and their possible inhibitory mechanisms are also reviewed. The application of biological control strategies and the discovery of new compounds with antifungal activity will reduce the resistance of C. albicans, thereby promoting the development of novel diverse antifungal drugs. MDPI 2022-09-12 /pmc/articles/PMC9495215/ /pubmed/36140017 http://dx.doi.org/10.3390/antibiotics11091238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Honghua
Yang, Jinpeng
Zhang, Xinwan
Xu, Xiuli
Song, Fuhang
Li, Hehe
Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
title Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
title_full Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
title_fullStr Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
title_full_unstemmed Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
title_short Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
title_sort biocontrol of candida albicans by antagonistic microorganisms and bioactive compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495215/
https://www.ncbi.nlm.nih.gov/pubmed/36140017
http://dx.doi.org/10.3390/antibiotics11091238
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