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Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia
Millions of patients acquire healthcare-associated infections (HAIs) every year, putting them at risk for serious complications and prolonged hospitalization. Point prevalence surveys (PPS), guided by the European Centre for Disease Prevention and Control framework, are one of the primary methods by...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495255/ https://www.ncbi.nlm.nih.gov/pubmed/36139941 http://dx.doi.org/10.3390/antibiotics11091161 |
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author | Ćirković, Ivana Marković-Denić, Ljiljana Bajčetić, Milica Dragovac, Gorana Đorđević, Zorana Mioljević, Vesna Urošević, Danijela Nikolić, Vladimir Despotović, Aleksa Krtinić, Gordana Rakić, Violeta Janićijević, Ivana Šuljagić, Vesna |
author_facet | Ćirković, Ivana Marković-Denić, Ljiljana Bajčetić, Milica Dragovac, Gorana Đorđević, Zorana Mioljević, Vesna Urošević, Danijela Nikolić, Vladimir Despotović, Aleksa Krtinić, Gordana Rakić, Violeta Janićijević, Ivana Šuljagić, Vesna |
author_sort | Ćirković, Ivana |
collection | PubMed |
description | Millions of patients acquire healthcare-associated infections (HAIs) every year, putting them at risk for serious complications and prolonged hospitalization. Point prevalence surveys (PPS), guided by the European Centre for Disease Prevention and Control framework, are one of the primary methods by which countries in the European Union conduct surveillance of HAIs. Serbia, though not in the EU, implemented this approach in its national PPS. The microbiological and antimicrobial resistance (AMR) analyses comprised patients in 61 out of 65 hospitals included in the fourth PPS conducted in November 2017. A total of 515/12,380 (4.2%) of the adult patients included in the PPS had at least one HAI, with intensive care units carrying the highest prevalence of 15.9%. Urinary tract and surgical site infections were the most frequently identified types of HAIs (23.9% and 23.0%, respectively). Enterobacterales comprised almost half (47.0%) of all causative agents, most notably Klebsiella spp. (16.7%). AMR was very high for most pathogens—80.5% of nonfermentative Gram-negative bacilli were resistant to carbapenems whereas 62.9% of Enterobacterales were resistant to third generation cephalosporins. The calculated AMR index of 61% is one of the highest in Europe. Further efforts are needed to reduce the burden of HAIs in Serbia that carry very high resistance rates to antibiotics currently used in clinical practice. |
format | Online Article Text |
id | pubmed-9495255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94952552022-09-23 Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia Ćirković, Ivana Marković-Denić, Ljiljana Bajčetić, Milica Dragovac, Gorana Đorđević, Zorana Mioljević, Vesna Urošević, Danijela Nikolić, Vladimir Despotović, Aleksa Krtinić, Gordana Rakić, Violeta Janićijević, Ivana Šuljagić, Vesna Antibiotics (Basel) Article Millions of patients acquire healthcare-associated infections (HAIs) every year, putting them at risk for serious complications and prolonged hospitalization. Point prevalence surveys (PPS), guided by the European Centre for Disease Prevention and Control framework, are one of the primary methods by which countries in the European Union conduct surveillance of HAIs. Serbia, though not in the EU, implemented this approach in its national PPS. The microbiological and antimicrobial resistance (AMR) analyses comprised patients in 61 out of 65 hospitals included in the fourth PPS conducted in November 2017. A total of 515/12,380 (4.2%) of the adult patients included in the PPS had at least one HAI, with intensive care units carrying the highest prevalence of 15.9%. Urinary tract and surgical site infections were the most frequently identified types of HAIs (23.9% and 23.0%, respectively). Enterobacterales comprised almost half (47.0%) of all causative agents, most notably Klebsiella spp. (16.7%). AMR was very high for most pathogens—80.5% of nonfermentative Gram-negative bacilli were resistant to carbapenems whereas 62.9% of Enterobacterales were resistant to third generation cephalosporins. The calculated AMR index of 61% is one of the highest in Europe. Further efforts are needed to reduce the burden of HAIs in Serbia that carry very high resistance rates to antibiotics currently used in clinical practice. MDPI 2022-08-28 /pmc/articles/PMC9495255/ /pubmed/36139941 http://dx.doi.org/10.3390/antibiotics11091161 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ćirković, Ivana Marković-Denić, Ljiljana Bajčetić, Milica Dragovac, Gorana Đorđević, Zorana Mioljević, Vesna Urošević, Danijela Nikolić, Vladimir Despotović, Aleksa Krtinić, Gordana Rakić, Violeta Janićijević, Ivana Šuljagić, Vesna Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia |
title | Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia |
title_full | Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia |
title_fullStr | Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia |
title_full_unstemmed | Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia |
title_short | Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia |
title_sort | microbiology of healthcare-associated infections: results of a fourth national point prevalence survey in serbia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495255/ https://www.ncbi.nlm.nih.gov/pubmed/36139941 http://dx.doi.org/10.3390/antibiotics11091161 |
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