IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4(+)Foxp3(+) regulatory T lymphocytes

Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR, co-stimulatory receptors, and cytokine receptors. In absence of IL-2, IL-15 or their receptors, fewer Treg apparently develop in the thymus. However, it...

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Detalles Bibliográficos
Autores principales: Apert, Cécile, Galindo-Albarrán, Ariel O., Castan, Sarah, Detraves, Claire, Michaud, Héloise, McJannett, Nicola, Haegeman, Bart, Fillatreau, Simon, Malissen, Bernard, Holländer, Georg, Žuklys, Saulius, Santamaria, Jérémy C., Joffre, Olivier P., Romagnoli, Paola, van Meerwijk, Joost P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495261/
https://www.ncbi.nlm.nih.gov/pubmed/36159793
http://dx.doi.org/10.3389/fimmu.2022.965303

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