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Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients

Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record lo...

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Autores principales: Prenassi, Marco, Borellini, Linda, Bocci, Tommaso, Scola, Elisa, Barbieri, Sergio, Priori, Alberto, Ferrucci, Roberta, Cogiamanian, Filippo, Locatelli, Marco, Rampini, Paolo, Vergari, Maurizio, Pastore, Stefano, Datola, Bianca, Marceglia, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495298/
https://www.ncbi.nlm.nih.gov/pubmed/36158622
http://dx.doi.org/10.3389/fnhum.2022.950434
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author Prenassi, Marco
Borellini, Linda
Bocci, Tommaso
Scola, Elisa
Barbieri, Sergio
Priori, Alberto
Ferrucci, Roberta
Cogiamanian, Filippo
Locatelli, Marco
Rampini, Paolo
Vergari, Maurizio
Pastore, Stefano
Datola, Bianca
Marceglia, Sara
author_facet Prenassi, Marco
Borellini, Linda
Bocci, Tommaso
Scola, Elisa
Barbieri, Sergio
Priori, Alberto
Ferrucci, Roberta
Cogiamanian, Filippo
Locatelli, Marco
Rampini, Paolo
Vergari, Maurizio
Pastore, Stefano
Datola, Bianca
Marceglia, Sara
author_sort Prenassi, Marco
collection PubMed
description Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record local field potentials (LFPs) which are used both to better understand basal ganglia pathophysiology and to improve DBS therapy. In this work, we investigated whether the presence of post-surgery edema correlates with the quality of LFP recordings in eight patients with advanced Parkinson’s disease implanted with subthalamic DBS electrodes. The magnetic resonance scans of the brain after 8.5 ± 1.5 days from the implantation surgery were segmented and the peri-electrode edema volume was calculated for both brain hemispheres. We found a correlation (ρ = −0.81, p < 0.0218, Spearman’s correlation coefficient) between left side local field potentials of the low beta band (11–20 Hz) and the edema volume of the same side. No other significant differences between the hemispheres were found. Despite the limited sample size, our results suggest that the effect on LFPs may be related to the edema localization, thus indicating a mechanism involving brain networks instead of a simple change in the electrode-tissue interface.
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spelling pubmed-94952982022-09-23 Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients Prenassi, Marco Borellini, Linda Bocci, Tommaso Scola, Elisa Barbieri, Sergio Priori, Alberto Ferrucci, Roberta Cogiamanian, Filippo Locatelli, Marco Rampini, Paolo Vergari, Maurizio Pastore, Stefano Datola, Bianca Marceglia, Sara Front Hum Neurosci Human Neuroscience Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record local field potentials (LFPs) which are used both to better understand basal ganglia pathophysiology and to improve DBS therapy. In this work, we investigated whether the presence of post-surgery edema correlates with the quality of LFP recordings in eight patients with advanced Parkinson’s disease implanted with subthalamic DBS electrodes. The magnetic resonance scans of the brain after 8.5 ± 1.5 days from the implantation surgery were segmented and the peri-electrode edema volume was calculated for both brain hemispheres. We found a correlation (ρ = −0.81, p < 0.0218, Spearman’s correlation coefficient) between left side local field potentials of the low beta band (11–20 Hz) and the edema volume of the same side. No other significant differences between the hemispheres were found. Despite the limited sample size, our results suggest that the effect on LFPs may be related to the edema localization, thus indicating a mechanism involving brain networks instead of a simple change in the electrode-tissue interface. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9495298/ /pubmed/36158622 http://dx.doi.org/10.3389/fnhum.2022.950434 Text en Copyright © 2022 Prenassi, Borellini, Bocci, Scola, Barbieri, Priori, Ferrucci, Cogiamanian, Locatelli, Rampini, Vergari, Pastore, Datola and Marceglia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Prenassi, Marco
Borellini, Linda
Bocci, Tommaso
Scola, Elisa
Barbieri, Sergio
Priori, Alberto
Ferrucci, Roberta
Cogiamanian, Filippo
Locatelli, Marco
Rampini, Paolo
Vergari, Maurizio
Pastore, Stefano
Datola, Bianca
Marceglia, Sara
Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
title Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
title_full Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
title_fullStr Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
title_full_unstemmed Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
title_short Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
title_sort peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495298/
https://www.ncbi.nlm.nih.gov/pubmed/36158622
http://dx.doi.org/10.3389/fnhum.2022.950434
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