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Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients
Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record lo...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495298/ https://www.ncbi.nlm.nih.gov/pubmed/36158622 http://dx.doi.org/10.3389/fnhum.2022.950434 |
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author | Prenassi, Marco Borellini, Linda Bocci, Tommaso Scola, Elisa Barbieri, Sergio Priori, Alberto Ferrucci, Roberta Cogiamanian, Filippo Locatelli, Marco Rampini, Paolo Vergari, Maurizio Pastore, Stefano Datola, Bianca Marceglia, Sara |
author_facet | Prenassi, Marco Borellini, Linda Bocci, Tommaso Scola, Elisa Barbieri, Sergio Priori, Alberto Ferrucci, Roberta Cogiamanian, Filippo Locatelli, Marco Rampini, Paolo Vergari, Maurizio Pastore, Stefano Datola, Bianca Marceglia, Sara |
author_sort | Prenassi, Marco |
collection | PubMed |
description | Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record local field potentials (LFPs) which are used both to better understand basal ganglia pathophysiology and to improve DBS therapy. In this work, we investigated whether the presence of post-surgery edema correlates with the quality of LFP recordings in eight patients with advanced Parkinson’s disease implanted with subthalamic DBS electrodes. The magnetic resonance scans of the brain after 8.5 ± 1.5 days from the implantation surgery were segmented and the peri-electrode edema volume was calculated for both brain hemispheres. We found a correlation (ρ = −0.81, p < 0.0218, Spearman’s correlation coefficient) between left side local field potentials of the low beta band (11–20 Hz) and the edema volume of the same side. No other significant differences between the hemispheres were found. Despite the limited sample size, our results suggest that the effect on LFPs may be related to the edema localization, thus indicating a mechanism involving brain networks instead of a simple change in the electrode-tissue interface. |
format | Online Article Text |
id | pubmed-9495298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94952982022-09-23 Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients Prenassi, Marco Borellini, Linda Bocci, Tommaso Scola, Elisa Barbieri, Sergio Priori, Alberto Ferrucci, Roberta Cogiamanian, Filippo Locatelli, Marco Rampini, Paolo Vergari, Maurizio Pastore, Stefano Datola, Bianca Marceglia, Sara Front Hum Neurosci Human Neuroscience Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record local field potentials (LFPs) which are used both to better understand basal ganglia pathophysiology and to improve DBS therapy. In this work, we investigated whether the presence of post-surgery edema correlates with the quality of LFP recordings in eight patients with advanced Parkinson’s disease implanted with subthalamic DBS electrodes. The magnetic resonance scans of the brain after 8.5 ± 1.5 days from the implantation surgery were segmented and the peri-electrode edema volume was calculated for both brain hemispheres. We found a correlation (ρ = −0.81, p < 0.0218, Spearman’s correlation coefficient) between left side local field potentials of the low beta band (11–20 Hz) and the edema volume of the same side. No other significant differences between the hemispheres were found. Despite the limited sample size, our results suggest that the effect on LFPs may be related to the edema localization, thus indicating a mechanism involving brain networks instead of a simple change in the electrode-tissue interface. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9495298/ /pubmed/36158622 http://dx.doi.org/10.3389/fnhum.2022.950434 Text en Copyright © 2022 Prenassi, Borellini, Bocci, Scola, Barbieri, Priori, Ferrucci, Cogiamanian, Locatelli, Rampini, Vergari, Pastore, Datola and Marceglia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Prenassi, Marco Borellini, Linda Bocci, Tommaso Scola, Elisa Barbieri, Sergio Priori, Alberto Ferrucci, Roberta Cogiamanian, Filippo Locatelli, Marco Rampini, Paolo Vergari, Maurizio Pastore, Stefano Datola, Bianca Marceglia, Sara Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
title | Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
title_full | Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
title_fullStr | Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
title_full_unstemmed | Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
title_short | Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
title_sort | peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495298/ https://www.ncbi.nlm.nih.gov/pubmed/36158622 http://dx.doi.org/10.3389/fnhum.2022.950434 |
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