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Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation
Data regarding the effects of crude extract of Commelina plants in oral cancer treatment are scarce. This present study aimed to assess the proliferation-modulating effects of the Commelina sp. (MECO) methanol extract on oral cancer cells in culture, Ca9-22, and CAL 27. MECO suppressed viability to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495315/ https://www.ncbi.nlm.nih.gov/pubmed/36139887 http://dx.doi.org/10.3390/antiox11091813 |
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author | Liu, Wangta Hsu, Yin-Yin Tang, Jen-Yang Cheng, Yuan-Bin Chuang, Ya-Ting Jeng, Jiiang-Huei Yen, Chia-Hung Chang, Hsueh-Wei |
author_facet | Liu, Wangta Hsu, Yin-Yin Tang, Jen-Yang Cheng, Yuan-Bin Chuang, Ya-Ting Jeng, Jiiang-Huei Yen, Chia-Hung Chang, Hsueh-Wei |
author_sort | Liu, Wangta |
collection | PubMed |
description | Data regarding the effects of crude extract of Commelina plants in oral cancer treatment are scarce. This present study aimed to assess the proliferation-modulating effects of the Commelina sp. (MECO) methanol extract on oral cancer cells in culture, Ca9-22, and CAL 27. MECO suppressed viability to a greater extent in oral cancer cells than in normal cells. MECO also induced more annexin V, apoptosis, and caspase signaling for caspases 3/8/9 in oral cancer cells. The preferential antiproliferation and apoptosis were associated with cellular and mitochondrial oxidative stress in oral cancer cells. Moreover, MECO also preferentially induced DNA damage in oral cancer cells by elevating γH2AX and 8-hydroxyl-2′-deoxyguanosine. The oxidative stress scavengers N-acetylcysteine or MitoTEMPO reverted these preferential antiproliferation mechanisms. It can be concluded that MECO is a natural product with preferential antiproliferation effects and exhibits an oxidative stress-associated mechanism in oral cancer cells. |
format | Online Article Text |
id | pubmed-9495315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94953152022-09-23 Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation Liu, Wangta Hsu, Yin-Yin Tang, Jen-Yang Cheng, Yuan-Bin Chuang, Ya-Ting Jeng, Jiiang-Huei Yen, Chia-Hung Chang, Hsueh-Wei Antioxidants (Basel) Article Data regarding the effects of crude extract of Commelina plants in oral cancer treatment are scarce. This present study aimed to assess the proliferation-modulating effects of the Commelina sp. (MECO) methanol extract on oral cancer cells in culture, Ca9-22, and CAL 27. MECO suppressed viability to a greater extent in oral cancer cells than in normal cells. MECO also induced more annexin V, apoptosis, and caspase signaling for caspases 3/8/9 in oral cancer cells. The preferential antiproliferation and apoptosis were associated with cellular and mitochondrial oxidative stress in oral cancer cells. Moreover, MECO also preferentially induced DNA damage in oral cancer cells by elevating γH2AX and 8-hydroxyl-2′-deoxyguanosine. The oxidative stress scavengers N-acetylcysteine or MitoTEMPO reverted these preferential antiproliferation mechanisms. It can be concluded that MECO is a natural product with preferential antiproliferation effects and exhibits an oxidative stress-associated mechanism in oral cancer cells. MDPI 2022-09-14 /pmc/articles/PMC9495315/ /pubmed/36139887 http://dx.doi.org/10.3390/antiox11091813 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Wangta Hsu, Yin-Yin Tang, Jen-Yang Cheng, Yuan-Bin Chuang, Ya-Ting Jeng, Jiiang-Huei Yen, Chia-Hung Chang, Hsueh-Wei Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation |
title | Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation |
title_full | Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation |
title_fullStr | Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation |
title_full_unstemmed | Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation |
title_short | Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation |
title_sort | methanol extract of commelina plant inhibits oral cancer cell proliferation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495315/ https://www.ncbi.nlm.nih.gov/pubmed/36139887 http://dx.doi.org/10.3390/antiox11091813 |
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