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The Current State of Knowledge in Biological Properties of Cirsimaritin

The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effe...

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Autores principales: Benali, Taoufiq, Jaouadi, Imane, Ghchime, Rokia, El Omari, Nasreddine, Harboul, Kaoutar, Hammani, Khalil, Rebezov, Maksim, Shariati, Mohammad Ali, Mubarak, Mohammad S., Simal-Gandara, Jesus, Zengin, Gokhan, Park, Moon-Nyeo, Kim, Bonglee, Mahmud, Shafi, Lee, Learn-Han, Bouyahya, Abdelhakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495358/
https://www.ncbi.nlm.nih.gov/pubmed/36139916
http://dx.doi.org/10.3390/antiox11091842
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author Benali, Taoufiq
Jaouadi, Imane
Ghchime, Rokia
El Omari, Nasreddine
Harboul, Kaoutar
Hammani, Khalil
Rebezov, Maksim
Shariati, Mohammad Ali
Mubarak, Mohammad S.
Simal-Gandara, Jesus
Zengin, Gokhan
Park, Moon-Nyeo
Kim, Bonglee
Mahmud, Shafi
Lee, Learn-Han
Bouyahya, Abdelhakim
author_facet Benali, Taoufiq
Jaouadi, Imane
Ghchime, Rokia
El Omari, Nasreddine
Harboul, Kaoutar
Hammani, Khalil
Rebezov, Maksim
Shariati, Mohammad Ali
Mubarak, Mohammad S.
Simal-Gandara, Jesus
Zengin, Gokhan
Park, Moon-Nyeo
Kim, Bonglee
Mahmud, Shafi
Lee, Learn-Han
Bouyahya, Abdelhakim
author_sort Benali, Taoufiq
collection PubMed
description The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions.
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spelling pubmed-94953582022-09-23 The Current State of Knowledge in Biological Properties of Cirsimaritin Benali, Taoufiq Jaouadi, Imane Ghchime, Rokia El Omari, Nasreddine Harboul, Kaoutar Hammani, Khalil Rebezov, Maksim Shariati, Mohammad Ali Mubarak, Mohammad S. Simal-Gandara, Jesus Zengin, Gokhan Park, Moon-Nyeo Kim, Bonglee Mahmud, Shafi Lee, Learn-Han Bouyahya, Abdelhakim Antioxidants (Basel) Review The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions. MDPI 2022-09-19 /pmc/articles/PMC9495358/ /pubmed/36139916 http://dx.doi.org/10.3390/antiox11091842 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Benali, Taoufiq
Jaouadi, Imane
Ghchime, Rokia
El Omari, Nasreddine
Harboul, Kaoutar
Hammani, Khalil
Rebezov, Maksim
Shariati, Mohammad Ali
Mubarak, Mohammad S.
Simal-Gandara, Jesus
Zengin, Gokhan
Park, Moon-Nyeo
Kim, Bonglee
Mahmud, Shafi
Lee, Learn-Han
Bouyahya, Abdelhakim
The Current State of Knowledge in Biological Properties of Cirsimaritin
title The Current State of Knowledge in Biological Properties of Cirsimaritin
title_full The Current State of Knowledge in Biological Properties of Cirsimaritin
title_fullStr The Current State of Knowledge in Biological Properties of Cirsimaritin
title_full_unstemmed The Current State of Knowledge in Biological Properties of Cirsimaritin
title_short The Current State of Knowledge in Biological Properties of Cirsimaritin
title_sort current state of knowledge in biological properties of cirsimaritin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495358/
https://www.ncbi.nlm.nih.gov/pubmed/36139916
http://dx.doi.org/10.3390/antiox11091842
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