Cargando…
The Current State of Knowledge in Biological Properties of Cirsimaritin
The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effe...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495358/ https://www.ncbi.nlm.nih.gov/pubmed/36139916 http://dx.doi.org/10.3390/antiox11091842 |
_version_ | 1784793998209056768 |
---|---|
author | Benali, Taoufiq Jaouadi, Imane Ghchime, Rokia El Omari, Nasreddine Harboul, Kaoutar Hammani, Khalil Rebezov, Maksim Shariati, Mohammad Ali Mubarak, Mohammad S. Simal-Gandara, Jesus Zengin, Gokhan Park, Moon-Nyeo Kim, Bonglee Mahmud, Shafi Lee, Learn-Han Bouyahya, Abdelhakim |
author_facet | Benali, Taoufiq Jaouadi, Imane Ghchime, Rokia El Omari, Nasreddine Harboul, Kaoutar Hammani, Khalil Rebezov, Maksim Shariati, Mohammad Ali Mubarak, Mohammad S. Simal-Gandara, Jesus Zengin, Gokhan Park, Moon-Nyeo Kim, Bonglee Mahmud, Shafi Lee, Learn-Han Bouyahya, Abdelhakim |
author_sort | Benali, Taoufiq |
collection | PubMed |
description | The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions. |
format | Online Article Text |
id | pubmed-9495358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94953582022-09-23 The Current State of Knowledge in Biological Properties of Cirsimaritin Benali, Taoufiq Jaouadi, Imane Ghchime, Rokia El Omari, Nasreddine Harboul, Kaoutar Hammani, Khalil Rebezov, Maksim Shariati, Mohammad Ali Mubarak, Mohammad S. Simal-Gandara, Jesus Zengin, Gokhan Park, Moon-Nyeo Kim, Bonglee Mahmud, Shafi Lee, Learn-Han Bouyahya, Abdelhakim Antioxidants (Basel) Review The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions. MDPI 2022-09-19 /pmc/articles/PMC9495358/ /pubmed/36139916 http://dx.doi.org/10.3390/antiox11091842 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Benali, Taoufiq Jaouadi, Imane Ghchime, Rokia El Omari, Nasreddine Harboul, Kaoutar Hammani, Khalil Rebezov, Maksim Shariati, Mohammad Ali Mubarak, Mohammad S. Simal-Gandara, Jesus Zengin, Gokhan Park, Moon-Nyeo Kim, Bonglee Mahmud, Shafi Lee, Learn-Han Bouyahya, Abdelhakim The Current State of Knowledge in Biological Properties of Cirsimaritin |
title | The Current State of Knowledge in Biological Properties of Cirsimaritin |
title_full | The Current State of Knowledge in Biological Properties of Cirsimaritin |
title_fullStr | The Current State of Knowledge in Biological Properties of Cirsimaritin |
title_full_unstemmed | The Current State of Knowledge in Biological Properties of Cirsimaritin |
title_short | The Current State of Knowledge in Biological Properties of Cirsimaritin |
title_sort | current state of knowledge in biological properties of cirsimaritin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495358/ https://www.ncbi.nlm.nih.gov/pubmed/36139916 http://dx.doi.org/10.3390/antiox11091842 |
work_keys_str_mv | AT benalitaoufiq thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT jaouadiimane thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT ghchimerokia thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT elomarinasreddine thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT harboulkaoutar thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT hammanikhalil thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT rebezovmaksim thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT shariatimohammadali thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT mubarakmohammads thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT simalgandarajesus thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT zengingokhan thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT parkmoonnyeo thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT kimbonglee thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT mahmudshafi thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT leelearnhan thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT bouyahyaabdelhakim thecurrentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT benalitaoufiq currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT jaouadiimane currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT ghchimerokia currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT elomarinasreddine currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT harboulkaoutar currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT hammanikhalil currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT rebezovmaksim currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT shariatimohammadali currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT mubarakmohammads currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT simalgandarajesus currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT zengingokhan currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT parkmoonnyeo currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT kimbonglee currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT mahmudshafi currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT leelearnhan currentstateofknowledgeinbiologicalpropertiesofcirsimaritin AT bouyahyaabdelhakim currentstateofknowledgeinbiologicalpropertiesofcirsimaritin |