Cargando…

Tenovin-1 Ameliorates Renal Fibrosis in High-Fat-Diet-Induced Diabetic Nephropathy via Antioxidant and Anti-Inflammatory Pathways

High-fat diet (HFD)-induced obesity has been involved in the development of diabetic nephropathy (DN). Tenovin-1, a potent selective SIRT1/2 inhibitor, regulates various target proteins. The present study evaluated the protective effect of Tenovin-1 against renal fibrosis in HFD-induced Zucker diabe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kundu, Amit, Gali, Sreevarsha, Sharma, Swati, Park, Jae Hyeon, Kyung, So Young, Kacew, Sam, Kim, In Su, Lee, Kwang Youl, Kim, Hyung Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495519/ https://www.ncbi.nlm.nih.gov/pubmed/36139886 http://dx.doi.org/10.3390/antiox11091812

Ejemplares similares

Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/(C) Mice
por: Kundu, Amit, et al.
Publicado: (2023)

Molineria recurvata Ameliorates Streptozotocin-Induced Diabetic Nephropathy through Antioxidant and Anti-Inflammatory Pathways
por: Dey, Prasanta, et al.
Publicado: (2022)

Tenovin-6 impairs autophagy by inhibiting autophagic flux
por: Yuan, Hongfeng, et al.
Publicado: (2017)

Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways
por: Yang, Hun Yong, et al.
Publicado: (2019)

EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats
por: Kundu, Amit, et al.
Publicado: (2020)

Correction: Tenovin-6 impairs autophagy by inhibiting autophagic flux
por: Yuan, Hongfeng, et al.
Publicado: (2018)

Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats
por: Lee, Yong Hee, et al.
Publicado: (2019)

Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
por: Bang, Minji, et al.
Publicado: (2019)

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6
por: MacCallum, Stephanie F., et al.
Publicado: (2013)

Heterogeneous Responses of Gastric Cancer Cell Lines to Tenovin-6 and Synergistic Effect with Chloroquine
por: Ke, Xiangyu, et al.
Publicado: (2020)

CBGA ameliorates inflammation and fibrosis in nephropathy
por: Suzuki, Sayuri, et al.
Publicado: (2023)

Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy
por: Yuan, Hongfeng, et al.
Publicado: (2017)

Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins
por: Walters, Hannah E., et al.
Publicado: (2019)

Attenuated Lymphatic Proliferation Ameliorates Diabetic Nephropathy and High-Fat Diet-Induced Renal Lipotoxicity
por: Kim, Yaeni, et al.
Publicado: (2019)

SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy
por: Liu, Lirong, et al.
Publicado: (2017)

Effective Delivery of Endogenous Antioxidants Ameliorates Diabetic Nephropathy
por: Park, Yongsoo, et al.
Publicado: (2015)

Metformin and tenovin‐6 synergistically induces apoptosis through LKB1‐independent SIRT1 down‐regulation in non‐small cell lung cancer cells
por: Lee, Bo Bin, et al.
Publicado: (2019)

Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis
por: Xu, Jingyu, et al.
Publicado: (2021)

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib
por: Ladds, Marcus J. G. W., et al.
Publicado: (2018)

Beneficial Effects of Sarpogrelate and Rosuvastatin in High Fat Diet/Streptozotocin-Induced Nephropathy in Mice
por: Kim, Dong-hyun, et al.
Publicado: (2016)

Augmenter of liver regeneration ameliorates renal fibrosis in rats with obstructive nephropathy
por: Chen, Guo-tao, et al.
Publicado: (2014)

Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response
por: Deng, Fei, et al.
Publicado: (2019)

Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation
por: Hirai, Sachiko, et al.
Publicado: (2014)

Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma
por: Dai, Wei, et al.
Publicado: (2016)

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a (1)H-NMR Method to Assess Deacetylase Activity
por: Pirrie, Lisa, et al.
Publicado: (2012)

WKYMVm ameliorates obesity by improving lipid metabolism and leptin signalling
por: Kang, Ji Hyeon, et al.
Publicado: (2023)

3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
por: Jung, Jeeyoun, et al.
Publicado: (2022)

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy
por: Liu, Kun, et al.
Publicado: (2019)

Promising therapeutic mechanism for Chinese herbal medicine in ameliorating renal fibrosis in diabetic nephropathy
por: Wang, Shengju, et al.
Publicado: (2023)

Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells
por: Jin, Yanli, et al.
Publicado: (2015)

Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy
por: Park, Yeon Su, et al.
Publicado: (2023)

Supplementation of Abelmoschus manihot Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice
por: Kim, Hwajin, et al.
Publicado: (2018)

Mesenchymal Stem Cells Ameliorate Renal Inflammation in Adriamycin-induced Nephropathy
por: Kim, Hyung Sook, et al.
Publicado: (2019)

Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis
por: Ram, Chetan, et al.
Publicado: (2023)

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy
por: Jiang, Mengjie, et al.
Publicado: (2019)

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice
por: Nguyễn-Thanh, Tùng, et al.
Publicado: (2018)

Drosophila as a Robust Model System for Assessing Autophagy: A Review
por: Demir, Esref, et al.
Publicado: (2023)

Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats
por: Sachan, Richa, et al.
Publicado: (2020)

Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy
por: Kim, Kyeong-Seok, et al.
Publicado: (2021)

Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice
por: Seo, Jung-Woo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_strbuopbqna6ktqgupgdprm1ud