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Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19
The formation of microthrombi in lung autopsies indicates the involvement of NETs in the immunopathogenesis of severe COVID-19. Therefore, supplements inhibiting NET formation, in association with drugs with fewer adverse effects, should be a relevant strategy to attenuate the disease. Resveratrol (...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495554/ https://www.ncbi.nlm.nih.gov/pubmed/36139764 http://dx.doi.org/10.3390/antiox11091690 |
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author | de Souza Andrade, Milena M. Leal, Vinicius N. C. Fernandes, Iara G. Gozzi-Silva, Sarah C. Beserra, Danielle R. Oliveira, Emily A. Teixeira, Franciane M. E. Yendo, Tatiana M. Sousa, Maria da Glória T. Teodoro, Walcy R. Oliveira, Luana de M. Alberca, Ricardo W. Aoki, Valéria Duarte, Alberto J. S. Sato, Maria N. |
author_facet | de Souza Andrade, Milena M. Leal, Vinicius N. C. Fernandes, Iara G. Gozzi-Silva, Sarah C. Beserra, Danielle R. Oliveira, Emily A. Teixeira, Franciane M. E. Yendo, Tatiana M. Sousa, Maria da Glória T. Teodoro, Walcy R. Oliveira, Luana de M. Alberca, Ricardo W. Aoki, Valéria Duarte, Alberto J. S. Sato, Maria N. |
author_sort | de Souza Andrade, Milena M. |
collection | PubMed |
description | The formation of microthrombi in lung autopsies indicates the involvement of NETs in the immunopathogenesis of severe COVID-19. Therefore, supplements inhibiting NET formation, in association with drugs with fewer adverse effects, should be a relevant strategy to attenuate the disease. Resveratrol (RESV) is a natural polyphenol with an important antiviral and antioxidant role. To modulate neutrophils from patients infected with SARS-CoV-2, we evaluated the in vitro effect of RESV on NET formation. Herein, we investigated 190 patients hospitalized with moderate, severe, and critical symptoms at Hospital das Clínicas, Brazil. We observed that neutrophilia in patients with severe COVID-19 infection is composed of neutrophils with activated profile able to release NET spontaneously. Notably, RESV decreased the neutrophil-activated status and the release of free DNA, inhibiting NET formation even under the specific PMA stimulus. At present, there is no evidence of the role of RESV in neutrophils from patients with COVID-19 infection. These findings suggest that adjunctive therapies with RESV may help decrease the inflammation of viral or bacterial infection, improving patient outcomes. |
format | Online Article Text |
id | pubmed-9495554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94955542022-09-23 Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 de Souza Andrade, Milena M. Leal, Vinicius N. C. Fernandes, Iara G. Gozzi-Silva, Sarah C. Beserra, Danielle R. Oliveira, Emily A. Teixeira, Franciane M. E. Yendo, Tatiana M. Sousa, Maria da Glória T. Teodoro, Walcy R. Oliveira, Luana de M. Alberca, Ricardo W. Aoki, Valéria Duarte, Alberto J. S. Sato, Maria N. Antioxidants (Basel) Article The formation of microthrombi in lung autopsies indicates the involvement of NETs in the immunopathogenesis of severe COVID-19. Therefore, supplements inhibiting NET formation, in association with drugs with fewer adverse effects, should be a relevant strategy to attenuate the disease. Resveratrol (RESV) is a natural polyphenol with an important antiviral and antioxidant role. To modulate neutrophils from patients infected with SARS-CoV-2, we evaluated the in vitro effect of RESV on NET formation. Herein, we investigated 190 patients hospitalized with moderate, severe, and critical symptoms at Hospital das Clínicas, Brazil. We observed that neutrophilia in patients with severe COVID-19 infection is composed of neutrophils with activated profile able to release NET spontaneously. Notably, RESV decreased the neutrophil-activated status and the release of free DNA, inhibiting NET formation even under the specific PMA stimulus. At present, there is no evidence of the role of RESV in neutrophils from patients with COVID-19 infection. These findings suggest that adjunctive therapies with RESV may help decrease the inflammation of viral or bacterial infection, improving patient outcomes. MDPI 2022-08-29 /pmc/articles/PMC9495554/ /pubmed/36139764 http://dx.doi.org/10.3390/antiox11091690 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Souza Andrade, Milena M. Leal, Vinicius N. C. Fernandes, Iara G. Gozzi-Silva, Sarah C. Beserra, Danielle R. Oliveira, Emily A. Teixeira, Franciane M. E. Yendo, Tatiana M. Sousa, Maria da Glória T. Teodoro, Walcy R. Oliveira, Luana de M. Alberca, Ricardo W. Aoki, Valéria Duarte, Alberto J. S. Sato, Maria N. Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 |
title | Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 |
title_full | Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 |
title_fullStr | Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 |
title_full_unstemmed | Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 |
title_short | Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 |
title_sort | resveratrol downmodulates neutrophil extracellular trap (net) generation by neutrophils in patients with severe covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495554/ https://www.ncbi.nlm.nih.gov/pubmed/36139764 http://dx.doi.org/10.3390/antiox11091690 |
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