Ribosome-Directed Therapies in Cancer

The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome bi...

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Autores principales: Temaj, Gazmend, Chichiarelli, Silvia, Eufemi, Margherita, Altieri, Fabio, Hadziselimovic, Rifat, Farooqi, Ammad Ahmad, Yaylim, Ilhan, Saso, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495564/
https://www.ncbi.nlm.nih.gov/pubmed/36140189
http://dx.doi.org/10.3390/biomedicines10092088
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author Temaj, Gazmend
Chichiarelli, Silvia
Eufemi, Margherita
Altieri, Fabio
Hadziselimovic, Rifat
Farooqi, Ammad Ahmad
Yaylim, Ilhan
Saso, Luciano
author_facet Temaj, Gazmend
Chichiarelli, Silvia
Eufemi, Margherita
Altieri, Fabio
Hadziselimovic, Rifat
Farooqi, Ammad Ahmad
Yaylim, Ilhan
Saso, Luciano
author_sort Temaj, Gazmend
collection PubMed
description The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation.
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spelling pubmed-94955642022-09-23 Ribosome-Directed Therapies in Cancer Temaj, Gazmend Chichiarelli, Silvia Eufemi, Margherita Altieri, Fabio Hadziselimovic, Rifat Farooqi, Ammad Ahmad Yaylim, Ilhan Saso, Luciano Biomedicines Review The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. Cancer diseases are associated with an increase in ribosome biogenesis and mutation of ribosomal proteins. The ribosome represents an attractive anti-cancer therapy target and several strategies are used to identify specific drugs. Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation. MDPI 2022-08-26 /pmc/articles/PMC9495564/ /pubmed/36140189 http://dx.doi.org/10.3390/biomedicines10092088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Temaj, Gazmend
Chichiarelli, Silvia
Eufemi, Margherita
Altieri, Fabio
Hadziselimovic, Rifat
Farooqi, Ammad Ahmad
Yaylim, Ilhan
Saso, Luciano
Ribosome-Directed Therapies in Cancer
title Ribosome-Directed Therapies in Cancer
title_full Ribosome-Directed Therapies in Cancer
title_fullStr Ribosome-Directed Therapies in Cancer
title_full_unstemmed Ribosome-Directed Therapies in Cancer
title_short Ribosome-Directed Therapies in Cancer
title_sort ribosome-directed therapies in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495564/
https://www.ncbi.nlm.nih.gov/pubmed/36140189
http://dx.doi.org/10.3390/biomedicines10092088
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AT hadziselimovicrifat ribosomedirectedtherapiesincancer
AT farooqiammadahmad ribosomedirectedtherapiesincancer
AT yaylimilhan ribosomedirectedtherapiesincancer
AT sasoluciano ribosomedirectedtherapiesincancer

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