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The Role of miR-29s in Human Cancers—An Update

MicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3’ untranslated region (3’-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer....

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Autores principales: Nguyen, Thuy T. P., Suman, Kamrul Hassan, Nguyen, Thong Ba, Nguyen, Ha Thi, Do, Duy Ngoc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495592/
https://www.ncbi.nlm.nih.gov/pubmed/36140219
http://dx.doi.org/10.3390/biomedicines10092121
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author Nguyen, Thuy T. P.
Suman, Kamrul Hassan
Nguyen, Thong Ba
Nguyen, Ha Thi
Do, Duy Ngoc
author_facet Nguyen, Thuy T. P.
Suman, Kamrul Hassan
Nguyen, Thong Ba
Nguyen, Ha Thi
Do, Duy Ngoc
author_sort Nguyen, Thuy T. P.
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3’ untranslated region (3’-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer. Their dysregulation alters the expression of their target genes, thereby exerting influence on different cellular pathways including cell proliferation, apoptosis, migration, and invasion, thereby contributing to carcinogenesis. In the present review, we aimed to provide an overview of the current knowledge on the miR-29s biological network and its functions in cancer, as well as its current and potential applications as a diagnostic and prognostic biomarker and/or a therapeutic target in major types of human cancer.
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spelling pubmed-94955922022-09-23 The Role of miR-29s in Human Cancers—An Update Nguyen, Thuy T. P. Suman, Kamrul Hassan Nguyen, Thong Ba Nguyen, Ha Thi Do, Duy Ngoc Biomedicines Review MicroRNAs (miRNAs) are small non-coding RNAs that directly bind to the 3’ untranslated region (3’-UTR) of the target mRNAs to inhibit their expression. The miRNA-29s (miR-29s) are suggested to be either tumor suppressors or oncogenic miRNAs that are strongly dysregulated in various types of cancer. Their dysregulation alters the expression of their target genes, thereby exerting influence on different cellular pathways including cell proliferation, apoptosis, migration, and invasion, thereby contributing to carcinogenesis. In the present review, we aimed to provide an overview of the current knowledge on the miR-29s biological network and its functions in cancer, as well as its current and potential applications as a diagnostic and prognostic biomarker and/or a therapeutic target in major types of human cancer. MDPI 2022-08-29 /pmc/articles/PMC9495592/ /pubmed/36140219 http://dx.doi.org/10.3390/biomedicines10092121 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen, Thuy T. P.
Suman, Kamrul Hassan
Nguyen, Thong Ba
Nguyen, Ha Thi
Do, Duy Ngoc
The Role of miR-29s in Human Cancers—An Update
title The Role of miR-29s in Human Cancers—An Update
title_full The Role of miR-29s in Human Cancers—An Update
title_fullStr The Role of miR-29s in Human Cancers—An Update
title_full_unstemmed The Role of miR-29s in Human Cancers—An Update
title_short The Role of miR-29s in Human Cancers—An Update
title_sort role of mir-29s in human cancers—an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495592/
https://www.ncbi.nlm.nih.gov/pubmed/36140219
http://dx.doi.org/10.3390/biomedicines10092121
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