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Role of HLA-I Structural Variants and the Polyreactive Antibodies They Generate in Immune Homeostasis

Cell-surface HLA-I molecules consisting of β2-microglobulin (β2m) associated heavy chains (HCs), referred to as Face-1, primarily present peptides to CD8+ T-cells. HCs consist of three α-domains, with selected amino acid sequences shared by all alleles of all six isoforms. The cell-surface HLA under...

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Detalles Bibliográficos
Autores principales:	Ravindranath, Mepur H., El Hilali, Fatiha, Amato-Menker, Carly J., El Hilali, Hajar, Selvan, Senthamil R., Filippone, Edward J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495617/ https://www.ncbi.nlm.nih.gov/pubmed/36134954 http://dx.doi.org/10.3390/antib11030058

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