Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic

In 829 hospital encounters for patients with COVID-19, 73.2% included orders for antibiotics; however, only 1.8% had respiratory cultures during the first 3 hospital days isolating bacteria. Case–control analysis of 30 patients and 96 controls found that each antibiotic day increased the risk of iso...

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Autores principales: Li, Catherine, Chapin, Ryan W., Mercuro, Nicholas J., Yen, Christina F., Gold, Howard S., Lee, Matthew S. L., McCoy, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495623/
https://www.ncbi.nlm.nih.gov/pubmed/36168468
http://dx.doi.org/10.1017/ash.2021.173
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author Li, Catherine
Chapin, Ryan W.
Mercuro, Nicholas J.
Yen, Christina F.
Gold, Howard S.
Lee, Matthew S. L.
McCoy, Christopher
author_facet Li, Catherine
Chapin, Ryan W.
Mercuro, Nicholas J.
Yen, Christina F.
Gold, Howard S.
Lee, Matthew S. L.
McCoy, Christopher
author_sort Li, Catherine
collection PubMed
description In 829 hospital encounters for patients with COVID-19, 73.2% included orders for antibiotics; however, only 1.8% had respiratory cultures during the first 3 hospital days isolating bacteria. Case–control analysis of 30 patients and 96 controls found that each antibiotic day increased the risk of isolating multidrug-resistant gram-negative bacteria (MDR-GNB) in respiratory cultures by 6.5%.
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spelling pubmed-94956232022-09-26 Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic Li, Catherine Chapin, Ryan W. Mercuro, Nicholas J. Yen, Christina F. Gold, Howard S. Lee, Matthew S. L. McCoy, Christopher Antimicrob Steward Healthc Epidemiol Concise Communication In 829 hospital encounters for patients with COVID-19, 73.2% included orders for antibiotics; however, only 1.8% had respiratory cultures during the first 3 hospital days isolating bacteria. Case–control analysis of 30 patients and 96 controls found that each antibiotic day increased the risk of isolating multidrug-resistant gram-negative bacteria (MDR-GNB) in respiratory cultures by 6.5%. Cambridge University Press 2021-07-23 /pmc/articles/PMC9495623/ /pubmed/36168468 http://dx.doi.org/10.1017/ash.2021.173 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Concise Communication
Li, Catherine
Chapin, Ryan W.
Mercuro, Nicholas J.
Yen, Christina F.
Gold, Howard S.
Lee, Matthew S. L.
McCoy, Christopher
Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
title Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
title_full Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
title_fullStr Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
title_full_unstemmed Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
title_short Diminishing returns, increasing risks: Impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (COVID-19) pandemic
title_sort diminishing returns, increasing risks: impact of antibiotic duration of therapy on respiratory bacterial isolates in hospitalized patients during the coronavirus disease 2019 (covid-19) pandemic
topic Concise Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495623/
https://www.ncbi.nlm.nih.gov/pubmed/36168468
http://dx.doi.org/10.1017/ash.2021.173
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