Cargando…
Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach
Intracerebral hemorrhage (ICH), the second most common subtype of stroke, remains a significant cause of morbidity and mortality worldwide. The pathological mechanism of ICH is very complex, and it has been demonstrated that oxidative stress (OS) plays an important role in the pathogenesis of ICH. P...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495708/ https://www.ncbi.nlm.nih.gov/pubmed/36139885 http://dx.doi.org/10.3390/antiox11091811 |
_version_ | 1784794085687558144 |
---|---|
author | Zheng, Yingyi Li, Ruoqi Fan, Xiang |
author_facet | Zheng, Yingyi Li, Ruoqi Fan, Xiang |
author_sort | Zheng, Yingyi |
collection | PubMed |
description | Intracerebral hemorrhage (ICH), the second most common subtype of stroke, remains a significant cause of morbidity and mortality worldwide. The pathological mechanism of ICH is very complex, and it has been demonstrated that oxidative stress (OS) plays an important role in the pathogenesis of ICH. Previous studies have shown that OS is a therapeutic target after ICH, and antioxidants have also achieved some benefits in the treatment of ICH. This review aimed to explore the promise of natural products therapy to target OS in ICH. We searched PubMed using the keywords “oxidative stress in intracerebral hemorrhage” and “natural products in intracerebral hemorrhage”. Numerous animal and cell studies on ICH have demonstrated the potent antioxidant properties of natural products, including polyphenols and phenolic compounds, terpenoids, alkaloids, etc. In summary, natural products such as antioxidants offer the possibility of treatment of OS after ICH. However, researchers still have a long way to go to apply these natural products for the treatment of ICH more widely in the clinic. |
format | Online Article Text |
id | pubmed-9495708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94957082022-09-23 Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach Zheng, Yingyi Li, Ruoqi Fan, Xiang Antioxidants (Basel) Review Intracerebral hemorrhage (ICH), the second most common subtype of stroke, remains a significant cause of morbidity and mortality worldwide. The pathological mechanism of ICH is very complex, and it has been demonstrated that oxidative stress (OS) plays an important role in the pathogenesis of ICH. Previous studies have shown that OS is a therapeutic target after ICH, and antioxidants have also achieved some benefits in the treatment of ICH. This review aimed to explore the promise of natural products therapy to target OS in ICH. We searched PubMed using the keywords “oxidative stress in intracerebral hemorrhage” and “natural products in intracerebral hemorrhage”. Numerous animal and cell studies on ICH have demonstrated the potent antioxidant properties of natural products, including polyphenols and phenolic compounds, terpenoids, alkaloids, etc. In summary, natural products such as antioxidants offer the possibility of treatment of OS after ICH. However, researchers still have a long way to go to apply these natural products for the treatment of ICH more widely in the clinic. MDPI 2022-09-14 /pmc/articles/PMC9495708/ /pubmed/36139885 http://dx.doi.org/10.3390/antiox11091811 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zheng, Yingyi Li, Ruoqi Fan, Xiang Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach |
title | Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach |
title_full | Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach |
title_fullStr | Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach |
title_full_unstemmed | Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach |
title_short | Targeting Oxidative Stress in Intracerebral Hemorrhage: Prospects of the Natural Products Approach |
title_sort | targeting oxidative stress in intracerebral hemorrhage: prospects of the natural products approach |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495708/ https://www.ncbi.nlm.nih.gov/pubmed/36139885 http://dx.doi.org/10.3390/antiox11091811 |
work_keys_str_mv | AT zhengyingyi targetingoxidativestressinintracerebralhemorrhageprospectsofthenaturalproductsapproach AT liruoqi targetingoxidativestressinintracerebralhemorrhageprospectsofthenaturalproductsapproach AT fanxiang targetingoxidativestressinintracerebralhemorrhageprospectsofthenaturalproductsapproach |