Cargando…
The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have docum...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495760/ https://www.ncbi.nlm.nih.gov/pubmed/36140242 http://dx.doi.org/10.3390/biomedicines10092139 |
_version_ | 1784794098512691200 |
---|---|
author | Saint-Laurent, Céline Mazeyrie, Laurène Tajan, Mylène Paccoud, Romain Castan-Laurell, Isabelle Valet, Philippe Edouard, Thomas Pradère, Jean-Philippe Dray, Cédric Yart, Armelle |
author_facet | Saint-Laurent, Céline Mazeyrie, Laurène Tajan, Mylène Paccoud, Romain Castan-Laurell, Isabelle Valet, Philippe Edouard, Thomas Pradère, Jean-Philippe Dray, Cédric Yart, Armelle |
author_sort | Saint-Laurent, Céline |
collection | PubMed |
description | The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have documented that SHP2 modulation disrupted glucose homeostasis, pointing out a relationship between its dysfunction and insulin resistance, and the therapeutic potential of its targeting. While studies from cellular or tissue-specific models concluded on both pros-and-cons effects of SHP2 on insulin resistance, recent data from integrated systems argued for an insulin resistance promoting role for SHP2, and therefore a therapeutic benefit of its inhibition. In this review, we will summarize the general knowledge of SHP2’s molecular, cellular, and physiological functions, explaining the pathophysiological impact of its dysfunctions, then discuss its protective or promoting roles in insulin resistance as well as the potency and limitations of its pharmacological modulation. |
format | Online Article Text |
id | pubmed-9495760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94957602022-09-23 The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? Saint-Laurent, Céline Mazeyrie, Laurène Tajan, Mylène Paccoud, Romain Castan-Laurell, Isabelle Valet, Philippe Edouard, Thomas Pradère, Jean-Philippe Dray, Cédric Yart, Armelle Biomedicines Review The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have documented that SHP2 modulation disrupted glucose homeostasis, pointing out a relationship between its dysfunction and insulin resistance, and the therapeutic potential of its targeting. While studies from cellular or tissue-specific models concluded on both pros-and-cons effects of SHP2 on insulin resistance, recent data from integrated systems argued for an insulin resistance promoting role for SHP2, and therefore a therapeutic benefit of its inhibition. In this review, we will summarize the general knowledge of SHP2’s molecular, cellular, and physiological functions, explaining the pathophysiological impact of its dysfunctions, then discuss its protective or promoting roles in insulin resistance as well as the potency and limitations of its pharmacological modulation. MDPI 2022-08-31 /pmc/articles/PMC9495760/ /pubmed/36140242 http://dx.doi.org/10.3390/biomedicines10092139 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Saint-Laurent, Céline Mazeyrie, Laurène Tajan, Mylène Paccoud, Romain Castan-Laurell, Isabelle Valet, Philippe Edouard, Thomas Pradère, Jean-Philippe Dray, Cédric Yart, Armelle The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? |
title | The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? |
title_full | The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? |
title_fullStr | The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? |
title_full_unstemmed | The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? |
title_short | The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? |
title_sort | tyrosine phosphatase shp2: a new target for insulin resistance? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495760/ https://www.ncbi.nlm.nih.gov/pubmed/36140242 http://dx.doi.org/10.3390/biomedicines10092139 |
work_keys_str_mv | AT saintlaurentceline thetyrosinephosphataseshp2anewtargetforinsulinresistance AT mazeyrielaurene thetyrosinephosphataseshp2anewtargetforinsulinresistance AT tajanmylene thetyrosinephosphataseshp2anewtargetforinsulinresistance AT paccoudromain thetyrosinephosphataseshp2anewtargetforinsulinresistance AT castanlaurellisabelle thetyrosinephosphataseshp2anewtargetforinsulinresistance AT valetphilippe thetyrosinephosphataseshp2anewtargetforinsulinresistance AT edouardthomas thetyrosinephosphataseshp2anewtargetforinsulinresistance AT praderejeanphilippe thetyrosinephosphataseshp2anewtargetforinsulinresistance AT draycedric thetyrosinephosphataseshp2anewtargetforinsulinresistance AT yartarmelle thetyrosinephosphataseshp2anewtargetforinsulinresistance AT saintlaurentceline tyrosinephosphataseshp2anewtargetforinsulinresistance AT mazeyrielaurene tyrosinephosphataseshp2anewtargetforinsulinresistance AT tajanmylene tyrosinephosphataseshp2anewtargetforinsulinresistance AT paccoudromain tyrosinephosphataseshp2anewtargetforinsulinresistance AT castanlaurellisabelle tyrosinephosphataseshp2anewtargetforinsulinresistance AT valetphilippe tyrosinephosphataseshp2anewtargetforinsulinresistance AT edouardthomas tyrosinephosphataseshp2anewtargetforinsulinresistance AT praderejeanphilippe tyrosinephosphataseshp2anewtargetforinsulinresistance AT draycedric tyrosinephosphataseshp2anewtargetforinsulinresistance AT yartarmelle tyrosinephosphataseshp2anewtargetforinsulinresistance |