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The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?

The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have docum...

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Autores principales: Saint-Laurent, Céline, Mazeyrie, Laurène, Tajan, Mylène, Paccoud, Romain, Castan-Laurell, Isabelle, Valet, Philippe, Edouard, Thomas, Pradère, Jean-Philippe, Dray, Cédric, Yart, Armelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495760/
https://www.ncbi.nlm.nih.gov/pubmed/36140242
http://dx.doi.org/10.3390/biomedicines10092139
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author Saint-Laurent, Céline
Mazeyrie, Laurène
Tajan, Mylène
Paccoud, Romain
Castan-Laurell, Isabelle
Valet, Philippe
Edouard, Thomas
Pradère, Jean-Philippe
Dray, Cédric
Yart, Armelle
author_facet Saint-Laurent, Céline
Mazeyrie, Laurène
Tajan, Mylène
Paccoud, Romain
Castan-Laurell, Isabelle
Valet, Philippe
Edouard, Thomas
Pradère, Jean-Philippe
Dray, Cédric
Yart, Armelle
author_sort Saint-Laurent, Céline
collection PubMed
description The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have documented that SHP2 modulation disrupted glucose homeostasis, pointing out a relationship between its dysfunction and insulin resistance, and the therapeutic potential of its targeting. While studies from cellular or tissue-specific models concluded on both pros-and-cons effects of SHP2 on insulin resistance, recent data from integrated systems argued for an insulin resistance promoting role for SHP2, and therefore a therapeutic benefit of its inhibition. In this review, we will summarize the general knowledge of SHP2’s molecular, cellular, and physiological functions, explaining the pathophysiological impact of its dysfunctions, then discuss its protective or promoting roles in insulin resistance as well as the potency and limitations of its pharmacological modulation.
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spelling pubmed-94957602022-09-23 The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? Saint-Laurent, Céline Mazeyrie, Laurène Tajan, Mylène Paccoud, Romain Castan-Laurell, Isabelle Valet, Philippe Edouard, Thomas Pradère, Jean-Philippe Dray, Cédric Yart, Armelle Biomedicines Review The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pathological outcomes when dysregulated. Many studies have documented that SHP2 modulation disrupted glucose homeostasis, pointing out a relationship between its dysfunction and insulin resistance, and the therapeutic potential of its targeting. While studies from cellular or tissue-specific models concluded on both pros-and-cons effects of SHP2 on insulin resistance, recent data from integrated systems argued for an insulin resistance promoting role for SHP2, and therefore a therapeutic benefit of its inhibition. In this review, we will summarize the general knowledge of SHP2’s molecular, cellular, and physiological functions, explaining the pathophysiological impact of its dysfunctions, then discuss its protective or promoting roles in insulin resistance as well as the potency and limitations of its pharmacological modulation. MDPI 2022-08-31 /pmc/articles/PMC9495760/ /pubmed/36140242 http://dx.doi.org/10.3390/biomedicines10092139 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saint-Laurent, Céline
Mazeyrie, Laurène
Tajan, Mylène
Paccoud, Romain
Castan-Laurell, Isabelle
Valet, Philippe
Edouard, Thomas
Pradère, Jean-Philippe
Dray, Cédric
Yart, Armelle
The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
title The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
title_full The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
title_fullStr The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
title_full_unstemmed The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
title_short The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
title_sort tyrosine phosphatase shp2: a new target for insulin resistance?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495760/
https://www.ncbi.nlm.nih.gov/pubmed/36140242
http://dx.doi.org/10.3390/biomedicines10092139
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