Cargando…

Pharmacological Inhibition of Inositol Hexakisphosphate Kinase 1 Protects Mice against Obesity-Induced Bone Loss

SIMPLE SUMMARY: Obesity and diabetes have detrimental impacts on skeletal health that result in an increased fracture risk and impaired fracture healing, conditions associated with significant morbidity and mortality and that are costly to treat. Managing obesity-induced bone loss is complicated by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boregowda, Siddaraju V., Nanjappa, Manjunatha K., Booker, Cori N., Strivelli, Jacqueline, Supper, Valentina M., Cooke, Paul S., Phinney, Donald G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495776/ https://www.ncbi.nlm.nih.gov/pubmed/36138736 http://dx.doi.org/10.3390/biology11091257

Ejemplares similares

Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts
por: Booker, Cori N., et al.
Publicado: (2021)

Author Correction: Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts
por: Booker, Cori N., et al.
Publicado: (2021)

Basal p53 expression is indispensable for mesenchymal stem cell integrity
por: Boregowda, Siddaraju V., et al.
Publicado: (2018)

Novel role for alpha-2-macroglobulin (A2M) as a disease modifying protein in senile osteoporosis
por: Boregowda, Siddaraju V., et al.
Publicado: (2023)

The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System
por: Heitmann, Tyler, et al.
Publicado: (2023)

Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice
por: Moritoh, Yusuke, et al.
Publicado: (2016)

Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair
por: Jadav, Rathan S., et al.
Publicado: (2013)

Inositol hexakisphosphate is required for Integrator function
por: Lin, Min-Han, et al.
Publicado: (2022)

Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
por: Bizzarri, Mariano, et al.
Publicado: (2016)

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
por: Wang, Qi, et al.
Publicado: (2015)

The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
por: Moritoh, Yusuke, et al.
Publicado: (2021)

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
por: Aguirre, Tim, et al.
Publicado: (2023)

IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet‐Induced Skeletal Involution
por: Boregowda, Siddaraju V., et al.
Publicado: (2017)

Inositol hexakisphosphate increases the size of platelet aggregates
por: Brehm, Maria A., et al.
Publicado: (2019)

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
por: Rajasekaran, Subu Surendran, et al.
Publicado: (2018)

Do mammals make all their own inositol hexakisphosphate?
por: Letcher, Andrew J., et al.
Publicado: (2008)

Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
por: Wormald, Michael, et al.
Publicado: (2017)

Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2
por: Li, Haiyan, et al.
Publicado: (2022)

Inositol Hexakisphosphate-Induced Autoprocessing of Large Bacterial Protein Toxins
por: Egerer, Martina, et al.
Publicado: (2010)

Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling
por: Nagpal, Latika, et al.
Publicado: (2022)

Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis
por: Shi, Yue, et al.
Publicado: (2022)

Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory
por: Kim, Min-Gyu, et al.
Publicado: (2020)

Phytate (Inositol Hexakisphosphate) in Soil and Phosphate Acquisition from Inositol Phosphates by Higher Plants. A Review
por: Gerke, Jörg
Publicado: (2015)

Quantifiable Metrics for Predicting MSC Therapeutic Efficacy
por: Boregowda, Siddaraju V, et al.
Publicado: (2016)

Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
por: Chanduri, Manasa, et al.
Publicado: (2016)

Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1
por: Fu, Chenglai, et al.
Publicado: (2018)

Simple synthesis of (32)P-labelled inositol hexakisphosphates for study of phosphate transformations
por: Whitfield, Hayley, et al.
Publicado: (2017)

Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles
por: Ricana, Clifton L., et al.
Publicado: (2020)

MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia
por: Ucuncu, Ekin, et al.
Publicado: (2020)

Influence of pH on the Cytotoxic Activity of Inositol Hexakisphosphate (IP6) in Prostate Cancer
por: Betton, Blandine, et al.
Publicado: (2011)

Inositol Hexakisphosphate Inhibits Osteoclastogenesis on RAW 264.7 Cells and Human Primary Osteoclasts
por: Arriero, María del Mar, et al.
Publicado: (2012)

Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
por: Helmis, Christina, et al.
Publicado: (2013)

Impacts of dietary calcium, phytate, and phytase on inositol hexakisphosphate degradation and inositol phosphate release in different segments of digestive tract of broilers
por: Li, W., et al.
Publicado: (2017)

Determination of neo- and d-chiro-Inositol Hexakisphosphate in Soils by Solution (31)P NMR Spectroscopy
por: Turner, Benjamin L., et al.
Publicado: (2012)

High‐resolution mass spectrometric analysis of myo‐inositol hexakisphosphate using electrospray ionisation Orbitrap
por: McIntyre, Catherine A., et al.
Publicado: (2017)

Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP(6))
por: Yu, Alvin, et al.
Publicado: (2020)

Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase
por: Cheung, Joyce C.Y., et al.
Publicado: (2008)

Corrigendum to ‘Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells’ [Cellular Signalling 46 (2018) 120–128]
por: Rajasekaran, Subu Surendran, et al.
Publicado: (2019)

Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors
por: Diallo, J-S, et al.
Publicado: (2008)

The Acetyltransferase Activity of the Bacterial Toxin YopJ of Yersinia Is Activated by Eukaryotic Host Cell Inositol Hexakisphosphate
por: Mittal, Rohit, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7vbvdfah2s0ldb5ojq1jvo8f5s