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Therapeutic Applications of the CRISPR-Cas System
The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495783/ https://www.ncbi.nlm.nih.gov/pubmed/36135023 http://dx.doi.org/10.3390/bioengineering9090477 |
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author | Kang, Kyungmin Song, Youngjae Kim, Inho Kim, Tae-Jung |
author_facet | Kang, Kyungmin Song, Youngjae Kim, Inho Kim, Tae-Jung |
author_sort | Kang, Kyungmin |
collection | PubMed |
description | The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications. |
format | Online Article Text |
id | pubmed-9495783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94957832022-09-23 Therapeutic Applications of the CRISPR-Cas System Kang, Kyungmin Song, Youngjae Kim, Inho Kim, Tae-Jung Bioengineering (Basel) Review The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has revolutionized genetic engineering due to its simplicity, stability, and precision since its discovery. This technology is utilized in a variety of fields, from basic research in medicine and biology to medical diagnosis and treatment, and its potential is unbounded as new methods are developed. The review focused on medical applications and discussed the most recent treatment trends and limitations, with an emphasis on CRISPR-based therapeutics for infectious disease, oncology, and genetic disease, as well as CRISPR-based diagnostics, screening, immunotherapy, and cell therapy. Given its promising results, the successful implementation of the CRISPR-Cas system in clinical practice will require further investigation into its therapeutic applications. MDPI 2022-09-15 /pmc/articles/PMC9495783/ /pubmed/36135023 http://dx.doi.org/10.3390/bioengineering9090477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kang, Kyungmin Song, Youngjae Kim, Inho Kim, Tae-Jung Therapeutic Applications of the CRISPR-Cas System |
title | Therapeutic Applications of the CRISPR-Cas System |
title_full | Therapeutic Applications of the CRISPR-Cas System |
title_fullStr | Therapeutic Applications of the CRISPR-Cas System |
title_full_unstemmed | Therapeutic Applications of the CRISPR-Cas System |
title_short | Therapeutic Applications of the CRISPR-Cas System |
title_sort | therapeutic applications of the crispr-cas system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495783/ https://www.ncbi.nlm.nih.gov/pubmed/36135023 http://dx.doi.org/10.3390/bioengineering9090477 |
work_keys_str_mv | AT kangkyungmin therapeuticapplicationsofthecrisprcassystem AT songyoungjae therapeuticapplicationsofthecrisprcassystem AT kiminho therapeuticapplicationsofthecrisprcassystem AT kimtaejung therapeuticapplicationsofthecrisprcassystem |