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Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics

Low blood concentrations of the diet-derived compound ergothioneine (ET) have been associated with cognitive impairment and cerebrovascular disease (CeVD) in cross-sectional studies, but it is unclear whether ET levels can predict subsequent cognitive and functional decline. Here, we examined the te...

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Autores principales: Wu, Liu-Yun, Kan, Cheuk Ni, Cheah, Irwin K., Chong, Joyce Ruifen, Xu, Xin, Vrooman, Henri, Hilal, Saima, Venketasubramanian, Narayanaswamy, Chen, Christopher P., Halliwell, Barry, Lai, Mitchell K.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495818/
https://www.ncbi.nlm.nih.gov/pubmed/36139790
http://dx.doi.org/10.3390/antiox11091717
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author Wu, Liu-Yun
Kan, Cheuk Ni
Cheah, Irwin K.
Chong, Joyce Ruifen
Xu, Xin
Vrooman, Henri
Hilal, Saima
Venketasubramanian, Narayanaswamy
Chen, Christopher P.
Halliwell, Barry
Lai, Mitchell K.P.
author_facet Wu, Liu-Yun
Kan, Cheuk Ni
Cheah, Irwin K.
Chong, Joyce Ruifen
Xu, Xin
Vrooman, Henri
Hilal, Saima
Venketasubramanian, Narayanaswamy
Chen, Christopher P.
Halliwell, Barry
Lai, Mitchell K.P.
author_sort Wu, Liu-Yun
collection PubMed
description Low blood concentrations of the diet-derived compound ergothioneine (ET) have been associated with cognitive impairment and cerebrovascular disease (CeVD) in cross-sectional studies, but it is unclear whether ET levels can predict subsequent cognitive and functional decline. Here, we examined the temporal relationships between plasma ET status and cognition in a cohort of 470 elderly subjects attending memory clinics in Singapore. All participants underwent baseline plasma ET measurements as well as neuroimaging for CeVD and brain atrophy. Neuropsychological tests of cognition and function were assessed at baseline and follow-up visits for up to five years. Lower plasma ET levels were associated with poorer baseline cognitive performance and faster rates of decline in function as well as in multiple cognitive domains including memory, executive function, attention, visuomotor speed, and language. In subgroup analyses, the longitudinal associations were found only in non-demented individuals. Mediation analyses showed that the effects of ET on cognition seemed to be largely explainable by severity of concomitant CeVD, specifically white matter hyperintensities, and brain atrophy. Our findings support further assessment of plasma ET as a prognostic biomarker for accelerated cognitive and functional decline in pre-dementia and suggest possible therapeutic and preventative measures.
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spelling pubmed-94958182022-09-23 Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics Wu, Liu-Yun Kan, Cheuk Ni Cheah, Irwin K. Chong, Joyce Ruifen Xu, Xin Vrooman, Henri Hilal, Saima Venketasubramanian, Narayanaswamy Chen, Christopher P. Halliwell, Barry Lai, Mitchell K.P. Antioxidants (Basel) Article Low blood concentrations of the diet-derived compound ergothioneine (ET) have been associated with cognitive impairment and cerebrovascular disease (CeVD) in cross-sectional studies, but it is unclear whether ET levels can predict subsequent cognitive and functional decline. Here, we examined the temporal relationships between plasma ET status and cognition in a cohort of 470 elderly subjects attending memory clinics in Singapore. All participants underwent baseline plasma ET measurements as well as neuroimaging for CeVD and brain atrophy. Neuropsychological tests of cognition and function were assessed at baseline and follow-up visits for up to five years. Lower plasma ET levels were associated with poorer baseline cognitive performance and faster rates of decline in function as well as in multiple cognitive domains including memory, executive function, attention, visuomotor speed, and language. In subgroup analyses, the longitudinal associations were found only in non-demented individuals. Mediation analyses showed that the effects of ET on cognition seemed to be largely explainable by severity of concomitant CeVD, specifically white matter hyperintensities, and brain atrophy. Our findings support further assessment of plasma ET as a prognostic biomarker for accelerated cognitive and functional decline in pre-dementia and suggest possible therapeutic and preventative measures. MDPI 2022-08-30 /pmc/articles/PMC9495818/ /pubmed/36139790 http://dx.doi.org/10.3390/antiox11091717 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Liu-Yun
Kan, Cheuk Ni
Cheah, Irwin K.
Chong, Joyce Ruifen
Xu, Xin
Vrooman, Henri
Hilal, Saima
Venketasubramanian, Narayanaswamy
Chen, Christopher P.
Halliwell, Barry
Lai, Mitchell K.P.
Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
title Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
title_full Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
title_fullStr Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
title_full_unstemmed Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
title_short Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics
title_sort low plasma ergothioneine predicts cognitive and functional decline in an elderly cohort attending memory clinics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495818/
https://www.ncbi.nlm.nih.gov/pubmed/36139790
http://dx.doi.org/10.3390/antiox11091717
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