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A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs

Automated segmentation of tuberculosis (TB)-consistent lesions in chest X-rays (CXRs) using deep learning (DL) methods can help reduce radiologist effort, supplement clinical decision-making, and potentially result in improved patient treatment. The majority of works in the literature discuss traini...

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Autores principales: Rajaraman, Sivaramakrishnan, Yang, Feng, Zamzmi, Ghada, Xue, Zhiyun, Antani, Sameer K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495849/
https://www.ncbi.nlm.nih.gov/pubmed/36134959
http://dx.doi.org/10.3390/bioengineering9090413
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author Rajaraman, Sivaramakrishnan
Yang, Feng
Zamzmi, Ghada
Xue, Zhiyun
Antani, Sameer K.
author_facet Rajaraman, Sivaramakrishnan
Yang, Feng
Zamzmi, Ghada
Xue, Zhiyun
Antani, Sameer K.
author_sort Rajaraman, Sivaramakrishnan
collection PubMed
description Automated segmentation of tuberculosis (TB)-consistent lesions in chest X-rays (CXRs) using deep learning (DL) methods can help reduce radiologist effort, supplement clinical decision-making, and potentially result in improved patient treatment. The majority of works in the literature discuss training automatic segmentation models using coarse bounding box annotations. However, the granularity of the bounding box annotation could result in the inclusion of a considerable fraction of false positives and negatives at the pixel level that may adversely impact overall semantic segmentation performance. This study evaluates the benefits of using fine-grained annotations of TB-consistent lesions toward training the variants of U-Net models and constructing their ensembles for semantically segmenting TB-consistent lesions in both original and bone-suppressed frontal CXRs. The segmentation performance is evaluated using several ensemble methods such as bitwise- AND, bitwise-OR, bitwise-MAX, and stacking. Extensive empirical evaluations showcased that the stacking ensemble demonstrated superior segmentation performance (Dice score: 0.5743, 95% confidence interval: (0.4055, 0.7431)) compared to the individual constituent models and other ensemble methods. To the best of our knowledge, this is the first study to apply ensemble learning to improve fine-grained TB-consistent lesion segmentation performance.
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spelling pubmed-94958492022-09-23 A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs Rajaraman, Sivaramakrishnan Yang, Feng Zamzmi, Ghada Xue, Zhiyun Antani, Sameer K. Bioengineering (Basel) Article Automated segmentation of tuberculosis (TB)-consistent lesions in chest X-rays (CXRs) using deep learning (DL) methods can help reduce radiologist effort, supplement clinical decision-making, and potentially result in improved patient treatment. The majority of works in the literature discuss training automatic segmentation models using coarse bounding box annotations. However, the granularity of the bounding box annotation could result in the inclusion of a considerable fraction of false positives and negatives at the pixel level that may adversely impact overall semantic segmentation performance. This study evaluates the benefits of using fine-grained annotations of TB-consistent lesions toward training the variants of U-Net models and constructing their ensembles for semantically segmenting TB-consistent lesions in both original and bone-suppressed frontal CXRs. The segmentation performance is evaluated using several ensemble methods such as bitwise- AND, bitwise-OR, bitwise-MAX, and stacking. Extensive empirical evaluations showcased that the stacking ensemble demonstrated superior segmentation performance (Dice score: 0.5743, 95% confidence interval: (0.4055, 0.7431)) compared to the individual constituent models and other ensemble methods. To the best of our knowledge, this is the first study to apply ensemble learning to improve fine-grained TB-consistent lesion segmentation performance. MDPI 2022-08-24 /pmc/articles/PMC9495849/ /pubmed/36134959 http://dx.doi.org/10.3390/bioengineering9090413 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rajaraman, Sivaramakrishnan
Yang, Feng
Zamzmi, Ghada
Xue, Zhiyun
Antani, Sameer K.
A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs
title A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs
title_full A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs
title_fullStr A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs
title_full_unstemmed A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs
title_short A Systematic Evaluation of Ensemble Learning Methods for Fine-Grained Semantic Segmentation of Tuberculosis-Consistent Lesions in Chest Radiographs
title_sort systematic evaluation of ensemble learning methods for fine-grained semantic segmentation of tuberculosis-consistent lesions in chest radiographs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495849/
https://www.ncbi.nlm.nih.gov/pubmed/36134959
http://dx.doi.org/10.3390/bioengineering9090413
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