Cargando…

Identification of Key Genes and Pathways in Genotoxic Stress Induced Endothelial Dysfunction: Results of Whole Transcriptome Sequencing

Atherosclerosis is a leading cause of cardiovascular morbidity and mortality worldwide. Endothelial disfunction underlying the atherogenesis can be triggered by genotoxic stress in endothelial cells. In the presented research whole transcriptome sequencing (RNA-seq) of human coronary artery (HCAEC)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sinitsky, Maxim, Sinitskaya, Anna, Shishkova, Daria, Tupikin, Alexey, Asanov, Maxim, Khutornaya, Maria, Kabilov, Marsel, Ponasenko, Anastasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495888/ https://www.ncbi.nlm.nih.gov/pubmed/36140167 http://dx.doi.org/10.3390/biomedicines10092067

Ejemplares similares

Atorvastatin Can Modulate DNA Damage Repair in Endothelial Cells Exposed to Mitomycin C
por: Sinitsky, Maxim, et al.
Publicado: (2023)

The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease
por: Ponasenko, Anastasia, et al.
Publicado: (2023)

Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity
por: Frolov, Alexey, et al.
Publicado: (2023)

Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature
por: Kutikhin, Anton G., et al.
Publicado: (2020)

Immune Response and Lipid Metabolism Gene Polymorphisms Are Associated with the Risk of Obesity in Middle-Aged and Elderly Patients
por: Ponasenko, Anastasia, et al.
Publicado: (2022)

Calciprotein Particles Cause Physiologically Significant Pro-Inflammatory Response in Endothelial Cells and Systemic Circulation
por: Shishkova, Daria, et al.
Publicado: (2022)

Calciprotein Particles Cause Endothelial Dysfunction under Flow
por: Shishkova, Daria, et al.
Publicado: (2020)

Endothelial Dysfunction in the Context of Blood–Brain Barrier Modeling
por: Kutikhin, A. G., et al.
Publicado: (2022)

Co-Culture of Primary Human Coronary Artery and Internal Thoracic Artery Endothelial Cells Results in Mutually Beneficial Paracrine Interactions
por: Shishkova, Daria, et al.
Publicado: (2020)

Calcium Phosphate Bions Cause Intimal Hyperplasia in Intact Aortas of Normolipidemic Rats through Endothelial Injury
por: Shishkova, Daria, et al.
Publicado: (2019)

Whole-Transcriptome Sequencing: A Powerful Tool for Vascular Tissue Engineering and Endothelial Mechanobiology
por: Kutikhin, Anton G., et al.
Publicado: (2018)

Draft Genome Sequence of the Probiotic Bifidobacterium longum subsp. longum Strain MC-42
por: Tupikin, Alexey E., et al.
Publicado: (2016)

Changes in the Transcriptome Caused by Mutations in the Ribosomal Protein uS10 Associated with a Predisposition to Colorectal Cancer
por: Tian, Yueming, et al.
Publicado: (2022)

Mutation at the Site of Hydroxylation in the Ribosomal Protein uL15 (RPL27a) Causes Specific Changes in the Repertoire of mRNAs Translated in Mammalian Cells
por: Zolotenkova, Elizaveta A., et al.
Publicado: (2023)

Deficiency of the Ribosomal Protein uL5 Leads to Significant Rearrangements of the Transcriptional and Translational Landscapes in Mammalian Cells
por: Babaylova, Elena S., et al.
Publicado: (2021)

Extended Evaluation of Viral Diversity in Lake Baikal through Metagenomics
por: Butina, Tatyana V., et al.
Publicado: (2021)

Human ribosomal protein eS1 is engaged in cellular events related to processing and functioning of U11 snRNA
por: Gopanenko, Alexander V., et al.
Publicado: (2017)

Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes
por: Gopanenko, Alexander V., et al.
Publicado: (2021)

Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit
por: Grosheva, Anastasia S., et al.
Publicado: (2017)

Reporter-recruiting bifunctional aptasensor for bioluminescent analytical assays
por: Davydova, Anna, et al.
Publicado: (2020)

mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site
por: Babaylova, Elena S, et al.
Publicado: (2020)

Reorganization of the Landscape of Translated mRNAs in NSUN2-Deficient Cells and Specific Features of NSUN2 Target mRNAs
por: Kossinova, Olga A., et al.
Publicado: (2022)

Mitochondrial DNA as a Candidate Marker of Multiple Organ Failure after Cardiac Surgery
por: Grigoriev, Evgeny, et al.
Publicado: (2022)

Complete Genome Sequence of a Western Siberian Lymantria dispar Multiple Nucleopolyhedrovirus Isolate
por: Kabilov, Marsel R., et al.
Publicado: (2015)

Knockdown of the Ribosomal Protein eL29 in Mammalian Cells Leads to Significant Changes in Gene Expression at the Transcription Level
por: Gopanenko, Alexander V., et al.
Publicado: (2020)

Evaluation of the Feasibility of Endothelial Colony-Forming Cells to Develop Tissue-Engineered Vascular Grafts Based on the Gene Expression Profile Analysis
por: Velikanova, E.A., et al.
Publicado: (2022)

Endothelial Cell Markers Are Inferior to Vascular Smooth Muscle Cells Markers in Staining Vasa Vasorum and Are Non-Specific for Distinct Endothelial Cell Lineages in Clinical Samples
por: Markova, Victoria, et al.
Publicado: (2023)

Comparative Metagenomic Profiling of Symbiotic Bacterial Communities Associated with Ixodes persulcatus, Ixodes pavlovskyi and Dermacentor reticulatus Ticks
por: Kurilshikov, Alexander, et al.
Publicado: (2015)

Early Postoperative Immunothrombosis of Bioprosthetic Mitral Valve and Left Atrium: A Case Report
por: Kostyunin, Alexander, et al.
Publicado: (2022)

Association of TLR and TREM-1 gene polymorphisms with atherosclerosis severity in a Russian population
por: Kutikhin, Anton G., et al.
Publicado: (2016)

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2023)

Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism
por: Feenstra, Lian, et al.
Publicado: (2023)

Flow-Seq Evaluation of Translation Driven by a Set of Natural Escherichia coli 5′-UTR of Variable Length
por: Komarova, Ekaterina S., et al.
Publicado: (2022)

Complete Genome Sequencing of Borrelia valaisiana and Borrelia afzelii Isolated from Ixodes persulcatus Ticks in Western Siberia
por: Kurilshikov, Alexander M., et al.
Publicado: (2014)

A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification
por: Ponasenko, Anastasia V., et al.
Publicado: (2016)

The application of the cytokinesis-block micronucleus assay on peripheral blood lymphocytes for the assessment of genome damage in long-term residents of areas with high radon concentration
por: Sinitsky, Maxim Yu., et al.
Publicado: (2014)

Metagenomic Analysis of Virioplankton from the Pelagic Zone of Lake Baikal
por: Potapov, Sergey A., et al.
Publicado: (2019)

Gene Analysis, Cloning, and Heterologous Expression of Protease from a Micromycete Aspergillus ochraceus Capable of Activating Protein C of Blood Plasma
por: Komarevtsev, Sergei K., et al.
Publicado: (2021)

Liquid drop of DNA libraries reveals total genome information
por: Terekhov, Stanislav S., et al.
Publicado: (2020)

Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity
por: Kozhieva, Madina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1idtjfamt6pb1f5p8eoln5o2hs