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MRI Detection of Hepatic N-Acetylcysteine Uptake in Mice

This proof-of-concept study looked at the feasibility of using a thiol–water proton exchange (i.e., CEST) MRI contrast to detect in vivo hepatic N-acetylcysteine (NAC) uptake. The feasibility of detecting NAC-induced glutathione (GSH) biosynthesis using CEST MRI was also investigated. The detectabil...

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Detalles Bibliográficos
Autores principales:	Chen, Johnny, Hwang, Dennis W., Chen, Yu-Wen, Chen, Tsai-Chen, Yadav, Nirbhay N., Stait-Gardner, Timothy, Price, William S., Zheng, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495914/ https://www.ncbi.nlm.nih.gov/pubmed/36140239 http://dx.doi.org/10.3390/biomedicines10092138

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