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Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy. We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cel...

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Detalles Bibliográficos
Autores principales:	Barbosa, Marta, Santos, Marta, de Sousa, Nídia, Duarte-Silva, Sara, Vaz, Ana Rita, Salgado, António J., Brites, Dora
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496075/ https://www.ncbi.nlm.nih.gov/pubmed/36140218 http://dx.doi.org/10.3390/biomedicines10092120

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